South Carolina - Significance region: Local
| Little River Baptist Church |
| Loch Dhu |
| Long Creek Academy |
| Lookaway Hall |
| Lorick, Preston C., House |
| Lucas, Dr. Thomas E., House |
| Lucas Family Cemetery |
| Lucas, Jonathan, House |
| Lutheran Theological Seminary Building: Beam Dormitory |
| Lybrand, Henry, Farm |
| Lydia Plantation |
| Lynchburg Presbyterian Church |
| Mack-Belk House |
| Magness-Humphries House |
| Magnolia |
| Magnolia Cemetery |
| Magnolia Cemetery |
| Magnolia Hall |
| Manne Building |
| Manning Commercial Historic District |
| Manning Library |
| Mann-Simons Cottage |
| Manor, The |
| Marine Barracks, Charleston Navy Yard |
| Marion High School |
| Marion Historic District |
| Marion Street Area Historic District |
| Marlboro County Training School |
| Marshfield |
| Marshlands Plantation House |
| Marysville School |
| Mason, Charles T., House |
| Maude Callen Clinic |
| Mayesville Historic District |
| Mayfair |
| McBee Methodist Church |
| McBride's Office Supply |
| McCall, Clarence, House |
| McClellanville Historic District |
| McCollum-Murray House |
| McCorkle-Fewell-Long House |
| McCormick County Courthouse |
| McCormick County Office Building |
| McCormick Train Station |
| McCoy, Benjamin, House |
| McCoy Farmstead |
| McCullough, Charles S., House |
| McDowell House |
| McGhee Block |
| McLaurin House |
| McLaurin-Roper-McColl Farmstead |
| McLeod Farmstead |
| McMaster School |
| McNair, A. M., House |
| McPhail Angus Farm |
| McWhirter House |
| Means-Gage House |
| Means House |
| Meetze, Maj. Henry A., House |
| Meggett, W. Gresham, High and Elementary School |
| Melrose Heights-Oak Lawn-Fairview Historic District |
| Memorial Hall |
| Merridun |
| Middleburg Park Historic District |
| Middleton's Plantation |
| Midfield Plantation |
| Midway Plantation |
| Mikell, Isaac Jenkins, House |
| Miller Brothers Cotton Warehouse |
| Mills House |
| Mills Mill |
| Mims, Britton, Place |
| Mitchell, Crowell, House |
| Mitchell, McKendree, House |
| Mitchell-Shealy House |
| Mizpah Methodist Church |
| Monaghan Mill |
| Montgomery Building |
| Montgomery, E.W., Cotton Warehouse |
| Montgomery, Walter Scott, House |
| Moon-Dominick House |
| Moore-Kinard House |
| Morgan House |
| Mosquito Beach Historic District |
| Moultrieville Historic District |
| Mountain Shoals Plantation |
| Mount Carmel Historic District |
| Mount Hebron Temperance Hall |
| Mount Pleasant Historic District |
| Mount Prospect Baptist Church |
| Mt. Olive Baptist Church |
| Mt. Pisgah A.M.E. Church |
| Mt. Pisgah Baptist Church |
| Mt. Zion Institute High School |
| Mt. Zion Presbyterian Church |
| Mt. Zion Rosenwald School |
| Mulberry Chapel Methodist Church |
| Mullins Commercial Historic District |
| Murray, Andrew B., Vocational School |
| Murrells Inlet Historic District |
Data from United States Park Service and Wikidata
