South Carolina - Significance region: Local
| Music Hall Evangelical Lutheran Church |
| Myrtle Beach Atlantic Coast Line Railroad Station |
| Myrtle Beach Downtown Historic District |
| Myrtle Heights-Oak Park Historic District |
| Myrtle Moor |
| National Guard Armory |
| Nation Ford Fish Weir |
| Nation Ford Road |
| Newberry County Memorial Hospital |
| Newberry Opera House |
| New Hope Farm |
| New Market |
| Nicholls-Crook House |
| Nickels-Milam House |
| North Anderson Historic District |
| North Columbia Fire Station No. 7 |
| Nuckolls-Jefferies House |
| Numertia Plantation |
| Oak Grove |
| Oak Island |
| Oakland Mill |
| Oakland Plantation |
| Oakland Plantation |
| Oakland Plantation House |
| Ocean Forest Country Club |
| Ocean Grove School |
| Oconee County Cage |
| Oconee County Courthouse |
| Octagon House |
| O'Donnell House |
| Old Batesburg Grade School |
| Old Batesburg-Leesville High School |
| Old Colleton County Jail |
| Old Courthouse |
| Old Courthouse |
| Old Ebenezer Church |
| Old Georgetown Road |
| Old Greenwood Cemetery |
| Old Greenwood High School |
| Old Horry County Courthouse |
| Old Pickens Jail |
| Old Pickens Presbyterian Church |
| Old Pilgrim Baptist Church Cemetery and Kilgore Family Cemetery |
| Old Presbyterian Church |
| Old Shandon Historic District |
| Old White Meeting House Ruins and Cemetery |
| Oliver, Peter M. and Alice, House |
| Olympia Armory |
| Olympia Mill School |
| Olympia Mill Village Historic District |
| Olympia Union Hall |
| Oolenoy Baptist Church Cemetery |
| Orangeburg City Cemetery |
| Orangeburg County Fair Main Exhibit Building |
| Orangeburg County Jail |
| Orangeburg Downtown Historic District |
| Orange Grove |
| Orr, Dr. Samuel Marshall, House |
| Otranto Plantation |
| Owen Building |
| Owings, John Calvin, House |
| Pacific Community Association Building |
| Pacolet Mill Office |
| Pacolet Mills Cloth Room and Warehouse |
| Pacolet Mills Historic District |
| Palmetto Theater |
| Palmetto Theatre |
| Parker High School Auditorium |
| Parrish's Motor Court |
| Patrick, Dr. John B., House |
| Peeples, Hattie J., House |
| Pelzer Manufacturing Company and Mill Village Historic District |
| Pelzer Presbyterian Church |
| Pendleton Cotton Mill |
| People's National Bank Building |
| Perry-McIlwain-McDow House |
| Phelps House |
| Phillips Community Historic District |
| Phinney, James, House |
| Piedmont Mill Stores Building |
| Pine Grove Rosenwald School |
| Pineland, The |
| Pine Street Elementary School |
| Pineville Historic District |
| Pinewood Depot |
| Plane Hill |
| Pleasant Grove School |
| Pleasant Hill Consolidated School |
| Pleasant Inn |
| Poe Hardware and Supply Company |
| Poinsett Hotel |
| Pomaria |
| Pon Pon Chapel |
| Porter Military Academy |
| Port Royal School |
| Powell, J. Davis, House |
| Poynor Junior High School |
| Pressley, Colonel John Gotea, House |
| Price, George R., House |
| Price, Raymond, House |
Data from United States Park Service and Wikidata
