South Carolina - Area of significance: Architecture
| Middleburg Plantation |
| Middleton's Plantation |
| Midfield Plantation |
| Midway Plantation |
| Mikell, Isaac Jenkins, House |
| Milldam Rice Mill and Rice Barn |
| Millford Plantation |
| Mills House |
| Millwood |
| Mims, Britton, Place |
| Mitchell, Crowell, House |
| Mitchell, McKendree, House |
| Mitchell-Shealy House |
| Mizpah Methodist Church |
| Monaghan Mill |
| Montgomery Building |
| Montgomery, Walter Scott, House |
| Monticello Methodist Church |
| Monticello Store and Post Office |
| Moon-Dominick House |
| Moore-Kinard House |
| Moore-Mann House |
| Morgan House |
| Morris Island Lighthouse |
| Moultrieville Historic District |
| Mountain Shoals Plantation |
| Mount Carmel A.M.E. Zion Campground |
| Mount Carmel Historic District |
| Mount Hope |
| Mount Olivet Presbyterian Church |
| Mount Pleasant Historic District |
| Mount Prospect Baptist Church |
| Mower, George, House |
| Mt. Olive Baptist Church |
| Mt. Pisgah A.M.E. Church |
| Mt. Pisgah Baptist Church |
| Mt. Zion Institute High School |
| Mt. Zion Presbyterian Church |
| Mt. Zion Rosenwald School |
| Mulberry Chapel Methodist Church |
| Mulberry Plantation |
| Mulberry Plantation (Chesnut House) |
| Mullins Commercial Historic District |
| Murray, Andrew B., Vocational School |
| Murrells Inlet Historic District |
| Myrtle Beach Atlantic Coast Line Railroad Station |
| Myrtle Heights-Oak Park Historic District |
| Myrtle Moor |
| Nance, Frederick, House |
| National Guard Armory |
| National Loan and Exchange Bank Building |
| Neal and Dixon's Warehouse |
| Newberry College Historic District |
| Newberry County Memorial Hospital |
| Newberry Historic District |
| Newberry Opera House |
| New Brookland Historic District |
| New Hope A.R.P. Church and Session House |
| New Hope Farm |
| New Market |
| Newry Historic District |
| Nicholls-Crook House |
| Nicholson, James, House |
| Nickels-Milam House |
| North Anderson Historic District |
| North Columbia Fire Station No. 7 |
| Nuckolls-Jefferies House |
| Numertia Plantation |
| Oak Grove |
| Oak Island |
| Oakland Mill |
| Oakland Plantation |
| Oakland Plantation |
| Oakland Plantation House |
| Oaklyn Plantation |
| Oakwood |
| Ocean Forest Country Club |
| Ocean Grove School |
| Oconee County Courthouse |
| Oconee State Park Historic District |
| Oconee Station and Richards House |
| O'Donnell House |
| Old Batesburg Grade School |
| Old Bethel United Methodist Church |
| Old Brass |
| Old Campus District, University of South Carolina |
| Old Cokesbury and Masonic Female College and Conference School |
| Old Colleton County Jail |
| Old Courthouse |
| Old Courthouse |
| Old Ebenezer Church |
| Old Greenwood High School |
| Old Horry County Courthouse |
| Old House Plantation |
| Old Marine Hospital |
| Old Pickens Presbyterian Church |
| Old Presbyterian Church |
| Old Shandon Historic District |
| Old Slave Mart |
| Old Stone Church and Cemetery |
Data from United States Park Service and Wikidata
