South Carolina - Area of significance: Architecture
| Old Stone House |
| Oliver, Peter M. and Alice, House |
| Olympia Armory |
| Olympia Mill |
| Olympia Mill Village Historic District |
| Orangeburg County Jail |
| Orangeburg Downtown Historic District |
| Orange Grove |
| Orange Grove Plantation |
| Otranto Plantation |
| Otranto Plantation Indigo Vats |
| Owen Building |
| Owings, John Calvin, House |
| Pacific Community Association Building |
| Pacolet Mill Office |
| Pacolet Mills Cloth Room and Warehouse |
| Pacolet Mills Historic District |
| Padgett's Creek Baptist Church |
| Palmetto Building |
| Palmetto Compress and Warehouse Company Building |
| Palmetto Theater |
| Palmetto Theatre |
| Paris Mountain State Park Historic District |
| Parker High School Auditorium |
| Parrish's Motor Court |
| Patrick, Dr. John B., House |
| Pee Dee River Rice Planters Historic District |
| Peeples, Hattie J., House |
| Pegues Place |
| Pelzer Manufacturing Company and Mill Village Historic District |
| Pelzer Presbyterian Church |
| Pendleton Cotton Mill |
| Pendleton Historic District |
| People's National Bank Building |
| Perry-McIlwain-McDow House |
| Peter's Point Plantation |
| Pettigru Street Historic District |
| Phelps House |
| Phinney, James, House |
| Piedmont Mill Stores Building |
| Pine Island Plantation Complex |
| Pineland, The |
| Pine Street Elementary School |
| Pineville Historic District |
| Pinopolis Historic District North |
| Pinopolis Historic District South |
| Plane Hill |
| Pleasant Hill Consolidated School |
| Pleasant Inn |
| Poinsett Bridge |
| Poinsett Hotel |
| Poinsett State Park Historic District |
| Pomaria |
| Pompion Hill Chapel |
| Porter Military Academy |
| Port Royal School |
| Powder Magazine |
| Powell, J. Davis, House |
| Presbyterian Manse |
| Presqui'ile |
| Pressley, Colonel John Gotea, House |
| Price, George R., House |
| Price, Raymond, House |
| Price's Mill |
| Price's Post Office |
| Prince Frederick's Chapel Ruins |
| Prince George Winyah Church (Episcopal) and Cemetery |
| Prospect Hill |
| Providence Methodist Church |
| Puritan Farm |
| Quattlebaum, C. P., House |
| Quattlebaum, C. P., Office |
| Quattlebaum, Paul, House |
| Quillen, Robert, Office and Library |
| Quinby Plantation House-Halidon Hill Plantation |
| Ram Cat Alley Historic District |
| Ramer, Ralph John, House |
| Rankin-Harwell House |
| Rasor and Clardy Company Building |
| Rauch, Charlton, House |
| Rawl-Couch House |
| Rawl, David, House |
| Rawl, John Jacob, House |
| Read Building |
| Redcliffe |
| Red Doe |
| Reid Street-North Confederate Avenue Area Historic District |
| Reidville Academy Faculty House |
| Reighley, Ike, House |
| Rembert Church |
| Republic Theater |
| Retreat Rosenwald School |
| Richardson-Godbold House |
| Richardson, J.C., House |
| Richland Cotton Mill |
| Richland Presbyterian Church |
| Richmond Plantation |
| Ridgeway Historic District |
| Rip Raps Plantation |
| Riverside Plantation Tabby Ruins |
Data from United States Park Service and Wikidata
