Florida - Significance region: Local
| Rowallan |
| Royal Park Arcade |
| Royal Poinciana Way Historic District |
| Rudolph, Paul, Sarasota High School Addition |
| Ruge Hall |
| Russell, Annie, Theatre |
| Russell, Judge Willis, House |
| Russ, Joseph W., Jr., House |
| Ryan & Company Lumber Yard |
| Ryburn Apartments |
| Sacred Heart Catholic Church |
| Saenger Theatre |
| Safford House |
| Saint Paul A.M.E. Church |
| Sample Estate |
| Sample-McDougald House |
| Sanchez Homestead |
| Sanderling Beach Club |
| Sanford Grammar School |
| Sanford Residential Historic District |
| Sanibel Colored School |
| Sanitary Public Market |
| San Jose Administration Building |
| San Jose Country Club |
| San Jose Estates Gatehouse |
| San Jose Hotel |
| San Juan De Aspalaga Site |
| San Pedro y San Pablo de Patale |
| Santa Rosa Hotel |
| Sapp House |
| Sarasota County Chamber of Commerce Building |
| Sarasota County Courthouse |
| Sarasota Garden Center |
| Sarasota Herald Building |
| Sarasota High School |
| Sarasota Times Building |
| Sarasota Woman's Club |
| Saxon, Frank, House |
| Scharnberg House |
| Schmidt-Godert Farm |
| Schueler, George, House |
| Scott Commercial Building |
| Seaboard Air Line Depot, Old-Sebring |
| Seaboard Airline Railroad Station |
| Seaboard Air Line Railway Station, Old |
| Seaboard Coast Line Railroad Depot |
| Seaboard Coastline Railroad Passenger Station |
| Seabreeze Historic District |
| Seagate |
| Sears, Roebuck and Company Department Store |
| Sebastian Grammar and Junior High School |
| Sebring Downtown Historic District |
| Sebring, H. Orvel, House |
| Security Building |
| Seminole Cafe and Hotel |
| Seminole County Home |
| Seminole Heights Residential District |
| Seminole Inn |
| Seybold Baking Company Factory |
| Shady Grove Primitive Baptist Church |
| Shelfer, E. B., House |
| Shell Hammock Landing |
| Sherman Arcade |
| Shoreland Arcade |
| Sikes House |
| Silver Palm Schoolhouse |
| Silver Springs |
| Singleton, Micajah T., House |
| Sloppy Joe's Bar |
| Smallwood, Ted, Store |
| Smith, Archie, Wholesale Fish Company |
| Smith, Dr. Chandler Holmes, House |
| Smith, E. C., House |
| Smith, H. W., Building |
| Smoky Hollow Historic District |
| Sneads Community House and Old Pump |
| Snell Arcade |
| Snyder Memorial Methodist Episcopal Church |
| Solla-Carcaba Cigar Factory |
| Sollner-Wall House |
| Sombrero Key Light |
| Sopchoppy Depot |
| Sopchoppy High School Gymnasium, Old |
| Sopchoppy School |
| Souder, Paul M., House |
| South Bartow Residential District |
| South Beach Street Historic District |
| South Brooksville Avenue Historic District |
| Southeast Gainesville Residential District |
| Southern Cassadaga Spiritualist Camp Historic District |
| South Florida Military College |
| South Jacksonville Grammar School |
| South Lake Morton Historic District |
| South Peninsula Historic District |
| South Ridgewood Elementary School |
| South River Drive Historic District |
| Southside School |
| South Side School |
| South Side School |
| South Third Street Historic District |
Data from United States Park Service and Wikidata
