Florida - Significance region: Local
| South Ward School |
| Southwest Daytona Beach Black Heritage District |
| Southwick-Harmon House |
| Spanish Apartments |
| Spell House |
| Spook Hill |
| Springfield Historic District |
| Spring Lake Community Center |
| S & S Sandwich Shop |
| St. Anastasia Catholic School, Old |
| Stanbury Cottage |
| Standard Oil Service Station |
| St. Andrew School |
| St. Andrew's Episcopal Church |
| St. Andrews Episcopal Church |
| St. Anthony School |
| Stanton, Edwin M., School |
| Star Garage |
| St. Augustine Alligator Farm Historic District |
| St. Augustine Civic Center |
| St. Augustine Public Burying Ground |
| St. Augustine Water Works |
| St. Cloud Depot |
| St. Cloud Downtown Historic District |
| Stephens House |
| Stevens, Ann, House |
| Stevens-Gilchrist House |
| St. George Episcopal Church |
| St. James A. M. E. Church |
| St. James Building |
| St. John's Baptist Church |
| St. John's Episcopal Church |
| St. Joseph Catholic Mission Church |
| St. Joseph's Catholic Church |
| St. Joseph's Church Buildings |
| St. Lucie High School |
| St. Lucie Village Historic District |
| St. Luke Baptist Church |
| St. Luke's Episcopal Church and Cemetery, Old |
| St. Margaret's Episcopal Church and Cemetery |
| St. Mark's Episcopal Church |
| St. Marks Episcopal Church |
| St. Mary Catholic Church |
| St. Mary's Church |
| St. Mary's Episcopal Church |
| St. Matthews Methodist Episcopal Church |
| St. Michael's Creole Benevolent Association Hall |
| Stockton-Lindquist House |
| Storm Wreck |
| Stovall House |
| St. Paul Lutheran Church |
| St. Petersburg Public Library |
| St. Petersburg Woman's Club |
| Stranahan House |
| Strawn Historic Agricultural District |
| Strawn Historic Citrus Packing House District |
| Strawn Historic Sawmill District |
| Strickland-Herold House |
| Strickland School |
| St. Rita's Colored Catholic Mission |
| Stuart Welcome Arch |
| Studebaker Building |
| Sugar Pot Site |
| Sundy, John and Elizabeth Shaw, House |
| Sunrise Theatre |
| Sunset Hotel |
| Sunshine State Arch |
| Surveyor's Lake Schoolhouse |
| Suwannee County Courthouse |
| Swearingen, John J., House |
| Sweeting Homestead |
| Tabby House |
| Taber Duplex |
| Talahloka |
| Taliaferro, T. C., House |
| Tall Timbers Plantation |
| Tampa Free Public Library, Old |
| Tampa Heights Historic District |
| Tampania House |
| Tampa Theater and Office Building |
| Tarpon Springs City Hall, Old |
| Tarpon Springs High School, Old |
| Tarpon Springs Historic District |
| Tarragona Tower |
| Taylor County Jail, Old |
| Taylor House |
| Taylor, Moses J., House |
| Temple Terrace Golf Course |
| Tenney House and Groveland Hotel |
| Terra Ceia Village Improvement Association Hall |
| Terry Park Ballfield |
| The Masonic Temple of Citrus, Lodge #18, F. and A.M. |
| Thiesen Building |
| "Thomas, Arden ""Doc"", House" |
| Thompson and Company Cigar Factory |
| Thompson Fish House, Turtle Cannery and Kraals |
| Thoms House |
| Thorpe, Alfred and Olive, Lustron House |
| Tice Grammer School |
| Tilden, Luther F., House |
Data from United States Park Service and Wikidata
