South Dakota - Significance region: Local
| Spearfish Filling Station |
| Spearfish Historic Commercial District |
| Spearfish Post Office (Old) |
| Spink County Courthouse |
| Split Rock Creek Park Historic District |
| Spring Creek School |
| Springer, R. D. and Mary, House |
| Spring Valley Township Bridge No. E-31 |
| Stadum-Green House |
| St. Andrew's Episcopal Church |
| St. Ann's Catholic Church of Badus |
| Stark and Blanch Garage |
| Stark Round Barn |
| Star School District 61 |
| State Soldiers Home Barn |
| St. Augustine Church |
| Stavig, Andrew and Mary, House |
| Stearns, William, Ranch |
| Stephens-Lucas House |
| Sterling Methodist Church |
| Steven's, Dr., House |
| Stevens Opera Block |
| Stevens Ranch |
| Stidworthy-Kemper House |
| St. John's Catholic Church |
| St. Lawrence O'Toole Catholic Church |
| St. Mary's Catholic Church |
| St. Mary's Church, School and Convent |
| Stocker, G. L., Blacksmith Shop |
| Stockgrowers Bank Building |
| Stock Yards State Bank and Tri-State Wholesale Grocery Co. |
| Stokes, Oliver O., House |
| Stonelake Bridge |
| St. Onge Schoolhouse |
| Stordahl, Olaf, Barn |
| St. Paul Lutheran Church and Cemetery |
| St. Peter's Catholic Church |
| St. Peter's Lutheran Church |
| Streeter, Norman B., Homestead |
| St. Scholastica Catholic Church |
| St. Scholastica Rectory |
| Sturgis Commercial Block |
| Sturgis High School |
| Sturgis Water Works Company Supply Works Site |
| St. Vincent's Hotel |
| St. Wenceslaus Catholic Church and Parish House |
| St. Williams Catholic Church |
| Sully County Courthouse |
| Sumner, Gaylord, House |
| Swander Bakery Building |
| Swanson House |
| Swedish Lutheran Church of Strandburg |
| Sweep Hotel |
| Tabor School |
| Tackett Underwood Building |
| Tallent, Annie, House |
| Tarbell, Dr., House |
| Telemarken Lutheran Church |
| Terrace Park and Japanese Gardens |
| Texaco Super Service Station |
| Thielman-Stoddard House |
| Thomas, Charles A., House |
| Thompson Farmstead |
| Thompson House |
| Thomson, James S., House |
| Tolefsons Beef Stock Farm |
| Tomahawk Lake Country Club |
| Toomey House |
| Towner, Francis Averill (T. A.) and Janet Leach, House |
| Triangle Ranch |
| Trierweiler, Dr. John, House |
| Tripp County Veteran's Memorial |
| Tri State Bakery |
| Trygstad Law and Commerce Building |
| Tubbs, Newton Seymour, House |
| Tucek-Sykora Farmstead |
| Tuntland, Peder and Helga, Farmstead |
| Turner, Frank and Clara, House |
| Turner Township Bridge No. SE-18 |
| Turton Jail |
| Tuthill, John W., Lumber Company |
| Uhlig, Otto L., House |
| Ulmer, J. W., House |
| Ulrickson Barn |
| Underwood United Methodist Church |
| United Brethren Church |
| United Brethren Church in Christ |
| United Church of Christ, Congregational |
| University Historic District |
| University of South Dakota Historic Core District |
| US Post Office and Courthouse-Aberdeen |
| Vale Bridge |
| Vale Cut Off Belle Fourche River Bridge |
| Vale School |
| Veal, Thomas J., Ranch |
| Vermillion-Andrew Carnegie Library |
| Vernon, Edgar, House |
| Vessey School |
| Viken, Nicholas Augustus, Homestead |
| Volga Auditorium |
Data from United States Park Service and Wikidata
