South Dakota - Significance region: Local
| Renner Ball Park |
| Renner Lutheran Sanctuary |
| Reynolds, Grant J., House |
| Reynolds, Joseph, Ranch Yard and Stage Stop |
| Rice Farm |
| Richards Cabins |
| Ries, Nicholas T., Farmstead |
| Riley, Almira, House |
| Rising Hail Colony |
| Roberts County Courthouse |
| Rockford No. 40 School |
| Roetzel, Ferdinand and Elizabeth, Ranch |
| Roosevelt School |
| Rosebud Hotel |
| Roslyn Auditorium |
| Rowe House |
| Royal Center School |
| Royhl, Adam and Minnie, House |
| Rudolph-Parke House |
| Ruth, Thomas, H. House |
| Ryman, Melchior, Farm |
| Saint Onge State Bank |
| Salem Church |
| Salem Church Parsonage |
| Salem Township Bridge Number E-1 |
| Sample-Lindblaum House |
| Scheurenbrand, Gottlieb and Friederike, House |
| Schmid, Mathias, Farm |
| Schmitt, Gottlieb, House |
| Schnaidt, Edward, House |
| Schnauber, Fred, House |
| Scotland Main Street Historic District |
| Scotland Residential Historic District |
| Scotland Royal Theater |
| Scotney, John Aaron, House |
| Scurr, Kenneth R., House |
| Seaman, Louis N. and Helen, House |
| Security State Bank |
| Security State Bank of Dante |
| Selby Opera House |
| Sexauer, George P., House |
| Sexauer Seed Company Historic District |
| Shakespeare Garden and Shay House |
| Shaw, Glenn W., House |
| Sheafe, Gen. Mark W., House |
| Sherman Historic District |
| Shevling, L. W., Ranch |
| Shriver-Johnson Building |
| Sievers School |
| Simmons House |
| Singsaas Lutheran Church |
| Sioux Falls Downtown Historic District |
| Sioux Falls Light and Power Hydro Electric Plant |
| Sisseton Agency Headquarters & Wacipi Grounds |
| Sisseton Carnegie Library |
| Sisseton School |
| Sitting Bull Crystal Cavern Dance Pavilion |
| Sitting Bull Monument |
| Sittner Farm |
| Skartvedt House |
| Slettebak Grocercies, Hardware and Opera House |
| Slip Up Creek Homestead |
| Small, Charles and Eleanor, House |
| Smith, William P., House |
| Snyder, L. E., House |
| Soper-Behymer Ranch |
| Sorum Cooperative Store |
| Sorum Hotel |
| South Dakota Department of Transportation Bridge No. 06-129-020 |
| South Dakota Department of Transportation Bridge No. 06-142-190 |
| South Dakota Department of Transportation Bridge No. 14-060-032 |
| South Dakota Department of Transportation Bridge No. 14-088-170 |
| South Dakota Department of Transportation Bridge No. 14-090-042 |
| South Dakota Department of Transportation Bridge No. 50-122-155 |
| South Dakota Department of Transportation Bridge No. 50-193-086 |
| South Dakota Department of Transportation Bridge No. 51-051-000 |
| South Dakota Department of Transportation Bridge No. 51-102-010 |
| South Dakota Department of Transportation Bridge No. 52-575-383 |
| South Dakota Department of Transportation Bridge No. 55-030-418 |
| South Dakota Department of Transportation Bridge No. 63-016-150 |
| South Dakota Department of Transportation Bridge No. 63-052-030 |
| South Dakota Department of Transportation Bridge No. 63-132-040 |
| South Dakota Department of Transportation Bridge No. 63-160-056 |
| South Dakota Department of Transportation Bridge No. 63-197-130 |
| South Dakota Department of Transportation Bridge No. 63-198-181 |
| South Dakota Department of Transportation Bridge No. 63-210-282 |
| South Dakota Dept. of Trans. Bridge No. 34-120-194 |
| South Dakota Dept. of Trans. Bridge No. 34-140-046 |
| South Dakota Dept of Trans. Bridge No. 34-202-072 |
| South Dakota Dept of Trans. Bridge No. 42-200-125 |
| South Dakota Dept. of Trans. Bridge No. 50-196-104 |
| South Dakota Dept. of Transportation Bridge No. 07-009-060 |
| South Dakota Dept. of Transportation Bridge No. 07-220-454 |
| South Dakota Dept. of Transportation Bridge No. 07-268-030 |
| South Dakota Dept. of Transportation Bridge No. 07-304-414 |
| South Dakota Dept. of Transportation Bridge No. 10-270-338 |
| South Dakota Stockgrowers Association Building |
| Southeast Merton School No. 19 |
| South Side Fire Station No. 3 |
| Spearfish City Hall |
Data from United States Park Service and Wikidata
