South Carolina - Significance region: National
| Fireproof Building |
| First Baptist Church |
| First Presbyterian Church |
| Fish Haul Archaeological Site (38BU805) |
| Florence National Cemetery |
| Folly North Site-38CH1213 |
| Fort Frederick |
| Fort Fremont Battery |
| Fort Fremont Hospital |
| Fort Hill |
| Fort Johnson/Powder Magazine |
| Fort Lyttelton Site |
| Fort Moore-Savano Town Site |
| Fort Motte Battle Site |
| Fort Palmetto |
| Fort Pringle |
| Fort Sumter National Monument |
| Fort Trenholm |
| Fripp, Edgar, Mausoleum, St. Helena Island Parish Church |
| Fripp, Isaac, House Ruins |
| Frogmore Plantation Complex |
| Georgetown Historic District |
| Georgetown Lighthouse |
| Gibbes, William, House |
| Graniteville Historic District |
| Green's Shell Enclosure |
| Green, The |
| Grimball, Paul, House Ruins |
| Hall, Ainsley, House |
| Hampton Plantation |
| Hanckel Mound |
| Hasell Point Site |
| Hazelius, Ernest L., House |
| Heyward, Dubose, House |
| Heyward-Washington House |
| Hibernian Hall |
| Historic Camden Revolutionary War Restoration |
| Hobcaw Barony |
| Holy Cross Episcopal Church |
| Hopsewee |
| Horse Island |
| Huguenot Church |
| Jackson's Furnace Site (38YK217) |
| Jenkins, Mary, Community Praise House |
| Joye Cottage |
| Kahal Kadosh Beth Elohim Synagogue |
| Keithfield Plantation |
| Keller Site |
| King's Creek Furnace Site (38CK71) |
| Kings Mountain National Military Park |
| Kirkley, Evy, Site |
| Lancaster County Courthouse |
| Lancaster County Jail |
| Lands End Road Tabby Ruins |
| Landsford Canal |
| Lawton Mounds |
| Lighthouse Point Shell Ring (38CH12) |
| Little Barnwell Island |
| Lower Long Cane Associate Reformed Presbyterian Church |
| Magnolia Plantation and Gardens |
| Manigault, Joseph, House |
| Manning Archeological Site |
| Manship Farmstead |
| Market Hall and Sheds |
| Marshlands |
| McCollum Fish Weir |
| McCrady's Tavern and Long Room |
| McDowell Site |
| Medway |
| Middleburg Plantation |
| Middleton Place |
| Milldam Rice Mill and Rice Barn |
| Millford Plantation |
| Mills, Clark, Studio |
| Minim Island Shell Midden (38GE46) |
| Morgan, Daniel, Monument |
| Mulberry Plantation |
| Mulberry Plantation (Chesnut House) |
| Musgrove's Mill Historic Battle Site |
| Nance, Frederick, House |
| Nesbitt's Limestone Quarry (38CK69) |
| Nightingale Hall Rice Mill Chimney |
| Ninety Six National Historic Site |
| Oaks, The |
| Old Bethel United Methodist Church |
| Old Marine Hospital |
| Old Slave Mart |
| Old Stone Church and Cemetery |
| Orange Grove Plantation |
| Parris Island Drydock and Commanding Generals House |
| Pee Dee River Rice Planters Historic District |
| Penn Center Historic District |
| Pine Island Plantation Complex |
| Pompion Hill Chapel |
| Pottersville |
| Powder Magazine |
| Prince George Winyah Church (Episcopal) and Cemetery |
| Pritchard, Paul, Shipyard |
| Progressive Club, The |
| Rainey, Joseph H., House |
Data from United States Park Service and Wikidata
