South Carolina - Significance region: National
| Red Bluff Flint Quarries |
| Rhett, Robert Barnwell, House |
| Richmond Hill Plantation Archeological Sites |
| Rip Raps Plantation |
| Riverside Plantation Tabby Ruins |
| Roper, Robert William, House |
| Rose Hill Plantation House |
| Rosemont Plantation |
| Rural Hall Plantation House |
| Russell, Nathaniel, House |
| Rutledge, Edward, House |
| Rutledge, Gov. John, House |
| Saluda Old Town Site |
| SAM Site |
| Sams Plantation Complex Tabby Ruins |
| Scott’s Branch High School |
| Seabrook, William, House |
| Sea Pines |
| Secessionville Historic District |
| Sewee Mound |
| Silver Bluff |
| Simmons-Edwards House |
| Simmons, Robert, House |
| Site of Old Charles Towne |
| Skull Creek |
| Smalls, Robert, House |
| Snee Farm-Charles Pinckney National Historic Site |
| Snow's Island |
| South Carolina National Bank of Charleston |
| South Carolina Railroad |
| South Carolina State Hospital, Mills Building |
| South Carolina Statehouse |
| Spanish Mount Point |
| SS WILLIAM LAWRENCE Shipwreck Site |
| St. Helena Parish Chapel of Ease Ruins |
| St. Helenaville Archaeological Site (38BU931) |
| St. James' Church, Goose Creek |
| St. James Episcopal Church, Santee |
| St. Michael's Episcopal Church |
| Stockade, The |
| Stono River Slave Rebellion Site |
| Stony Point |
| St. Philip's Episcopal Church |
| St. Stephen's Episcopal Church |
| Stuart, Col. John, House |
| Summer Chapel, Prince Frederick's Episcopal Church |
| Summer Chapel Rectory, Prince Frederick's Episcopal Church |
| Summerton High School |
| Thicketty Mountain Ore Pits (38CK74) |
| Trapp and Chandler Pottery Site (38GN169) |
| Unitarian Church |
| Unnamed Battery |
| Unnamed Battery No. 1 |
| USS LAFFEY |
| USS YORKTOWN (CV-10) |
| Vesey, Denmark, House |
| Veterans Hospital |
| Waxhaw Presbyterian Church Cemetery |
| Weehaw Rice Mill Chimney |
| Williams Place |
| Wilson, Thomas Woodrow, Boyhood Home |
| Woodlands |
Data from United States Park Service and Wikidata
