South Carolina - Significance region: National
| Adamson Mounds Site |
| Aiken Mile Track |
| Aiken Training Track |
| Aiken, William, House and Associated Railroad Structures |
| Allendale Chert Quarries Archeological District |
| All Star Bowling Lane |
| Alston, Emanuel, House |
| Arcadia Plantation |
| Archeological Site 38CK1 |
| Archeological Site 38CK44 |
| Archeological Site 38CK45 |
| Archeological Site 38SP11 |
| Archeological Site 38SP12 |
| Archeological Site 38SP13 |
| Archeological Site 38SP17 |
| Archeological Site 38SP18 |
| Archeological Site 38SP19 |
| Archeological Site 38SP20 |
| Archeological Site 38SP21 |
| Archeological Site 38SP23 |
| Archeological Site 38SP52 |
| Archeological Site 38SP53 |
| Archeological Site 38SP54 |
| Archeological Site 38SP57 |
| Ashley Hall Plantation |
| Ashley River Road |
| Atalaya |
| Auld Mound |
| Bache, Alexander, U.S. Coast Survey Line |
| Bailey, Dr. York, House |
| Bass Pond Site |
| Battery Cheves |
| Battery LeRoy |
| Battery No. 1 |
| Battery No. 5 |
| Battery Tynes |
| Battery White |
| Battery Wilkes |
| Battle of Blackstock's Historic Site |
| Battle of Hanging Rock Historic Site |
| Beaufort Historic District |
| Beaufort National Cemetery |
| Belle Isle Rice Mill Chimney |
| Beneventum Plantation House |
| Bethesda Presbyterian Church |
| Blacklock, William, House |
| Blair Mound |
| Borough House Plantation |
| Branford-Horry House |
| Brewton, Miles, House |
| Brewton, Robert, House |
| Brick House Ruin |
| Brookgreen Gardens |
| BROWN'S FERRY VESSEL |
| Buford's Massacre Site |
| Burt, Armistead, House |
| Buyck's Bluff Archeological Site |
| Buzzard's Island Site |
| Calhoun, Patrick, Family Cemetery |
| Camden Battlefield |
| Camp Saxton Site |
| Chapelle Administration Building |
| Charlesfort-Santa Elena Site |
| Charleston Historic District |
| Charleston Historic District |
| Charleston Navy Yard Historic District |
| Charleston Navy Yard Officers' Quarters Historic District |
| Charleston's French Quarter District |
| Chester Field |
| Chicora Wood Plantation |
| Circular Congregational Church and Parish House |
| Citizens and Southern National Bank of South Carolina |
| City of Camden Historic District |
| Coffin Point Plantation Caretaker's House |
| Coker Experimental Farms |
| College of Charleston |
| Columbia Canal |
| Columbia City Hall |
| Columbia Historic District I |
| Columbia Historic District II |
| Coming Street Cemetery |
| Confederate Printing Plant |
| """Congarees"" Site" |
| Cooper River Historic District |
| Coopersville Ironworks Site (38CK2) and Susan Furnace Site (38CK67) |
| Corner Packing Shed, The |
| Corner Store and Office, The |
| Cowpens Furnace Site (38CK73) |
| Cowpens National Battlefield |
| Daufuskie Island Historic District |
| Dock Street Theatre |
| Drayton Hall |
| Eddings Point Community Praise House |
| Ellen Furnace Site (38CK68) |
| Eutaw Springs Battleground Park |
| Exchange and Provost |
| Fairfield Rice Mill Chimney |
| Farmers' and Exchange Bank |
| Fenwick Hall |
| Fig Island Site |
Data from United States Park Service and Wikidata
