South Carolina - Significance region: Local
| South Main Historic District |
| South Street-South Church Street Historic District |
| Spann, Dr. Cyril O., Medical Office |
| Spann Methodist Church and Cemetery |
| Sparrow, James, House |
| Spartanburg Historic District |
| Spencer House |
| Spigner, A. Fletcher, House |
| Spratt Cemetery |
| Springfield High School |
| Spring Park Inn |
| Spring Street Methodist Church |
| Springwood Cemetery |
| Standard Oil Company Headquarters |
| St. Andrew's Episcopal Church |
| Startex Finishing Company |
| State Theatre |
| Stevens-Dorn Farmstead |
| Stewart, James, House |
| St. George Rosenwald School |
| Still Hopes |
| St. James the Greater Catholic Mission |
| St. John's Historic District |
| St. John's Lutheran Church |
| St. John's Lutheran Church |
| St. Julien Plantation |
| St. Luke's Church |
| St. Luke's Parish Zion Chapel of Ease Cemetery |
| St. Michael's Evangelical Lutheran Church |
| Stokes-Mayfield House |
| Stone Manufacturing Company |
| Stoney Creek Independent Presbyterian Chapel of Prince William Parish |
| St. Paul's Methodist Church |
| St. Peter's Roman Catholic Church |
| St. Philip's Episcopal Church, Bradford Springs |
| St. Phillip School |
| Strawberry Chapel and Childsbury Town Site |
| Stroman, William P., House |
| Strother Place, Old |
| St. Stephen's Episcopal Church |
| St. Thaddeus Episcopal Church |
| Sturgis, R.L. and Annie, House |
| Sturkey, M. L. B., House |
| Sullivan House |
| Sullivan's Island Historic District |
| Summit Plantation House |
| Sumter Historic District |
| Sumter Town Hall-Opera House |
| Sun Fun Motel |
| Sunnyside |
| Sunnyside |
| Supreme Court of South Carolina Building |
| Sylvan Building |
| Sylvania |
| Tabernacle Cemetery |
| Tall Oaks |
| Taveau Church |
| Tawana Motel |
| Taylor, Earle R., House and Peach Packing Shed |
| Taylor House |
| Temple Sinai |
| Tennent, Josiah Smith, House |
| The Oaks |
| Thornwell-Elliott House |
| Thurmond, Strom, Federal Building and U.S. Courthouse |
| Tillman School |
| Tombee Plantation |
| Townsend's, Hephzibah Jenkins, Tabby Oven Ruins |
| Town Theatre |
| Treadwell Street Historic District |
| Triangle Building |
| Trinity Episcopal Church |
| Trinity Episcopal Church and Cemetery |
| Trinity Lutheran Church |
| Turner, Robert G., House |
| Turner, R. Perry, House |
| Ulmer-Summers House |
| Union Church of Port Royal |
| Union Community Hospital |
| Union National Bank Building |
| United States Post Office and Court House |
| United States Post Office and Court House |
| Unity Presbyterian Church Complex |
| University Neighborhood Historic District |
| US Court House-Aiken, South Carolina |
| U.S. Customhouse |
| U.S. Highway 25 |
| U.S. Post Office |
| U.S. Post Office and Courthouse |
| U.S. Post Office and Courthouse |
| US Post Office and Courthouse |
| Valencia |
| Veterans Administration Regional Office |
| Waccamaw River Memorial Bridge |
| Waccamaw River Warehouse Historic District |
| Wade-Beckham House |
| Waikiki Village Motel |
| Walhalla Graded School |
| Walhalla High School |
| Wall, B. C., House |
Data from United States Park Service and Wikidata
