South Carolina - Significance region: Local
| Walterboro Historic District |
| Ware Shoals Inn |
| Warren Mill |
| Warrenville Elementary School |
| Washington. Booker T., High School Auditorium |
| Washington Street United Methodist Church |
| Waverly Historic District |
| Webb-Coleman House |
| Wedge, The |
| Welborn, F.W., House |
| Wescott Road |
| Wesley, John, Methodist Episcopal Church |
| Wesley Methodist Church |
| Wessinger, Vastine, House |
| West Broad Street Historic District |
| West College Avenue Historic District |
| West End Commercial Historic District |
| West Gervais Street Historic District |
| West Main Street Historic District |
| West Point Rice Mill |
| White Church |
| White, Elizabeth, House |
| Whitehall |
| Whitehall |
| White House |
| White House United Methodist Church |
| White Plains |
| Whitman Street Area Historic District |
| Wicklow Hall Plantation |
| Wilds-Edwards House |
| Wilds Hall |
| Wilkinson-Boineau House |
| Wilkins, William and Harriet, House |
| Willcox's |
| Williams, A.P., Funeral Home |
| Williams-Ball-Copeland House |
| Williams Chapel A.M.E. Church |
| Williams House |
| Williams-Ligon House |
| Williamson, Mrs. B. F., House |
| Williams, Tom, House |
| Willow Consolidated High School |
| Wilson-Clary House |
| Wilson House |
| Wilson House |
| Wilson, John Calvin, House |
| Wilson, Monroe, House |
| Winborne, W. H., House |
| Windsor Plantation |
| Winyah Indigo School |
| Witherspoon-Hunter House |
| Woodland Plantation |
| Woodlawn |
| Woodruff High School |
| Woodside Cotton Mill Village Historic District |
| Woodson Farmstead |
| Working Benevolent Temple and Professional Building |
| Wright, Mary H., Elementary School |
| Wyche, C. Granville, House |
| Yarborough, Rev. Frank, House |
| York Graded School |
| Young Place |
| Zante Plantation |
| Zion Baptist Church |
Data from United States Park Service and Wikidata
