South Carolina - Significance region: Local
| Price's Mill |
| Prince Frederick's Chapel Ruins |
| Prospect Hill |
| Prosperity Cemetery |
| Providence Methodist Church |
| Puritan Farm |
| Quattlebaum, C. P., House |
| Quattlebaum, C. P., Office |
| Quattlebaum, Paul, House |
| Quillen, Robert, Office and Library |
| Quinby Plantation House-Halidon Hill Plantation |
| Ram Cat Alley Historic District |
| Rasor and Clardy Company Building |
| Rauch, Charlton, House |
| Ravenwood Plantation |
| Rawl-Couch House |
| Rawl, David, House |
| Rawl, John Jacob, House |
| Read Building |
| Red Doe |
| Reid Street-North Confederate Avenue Area Historic District |
| Reidville Academy Faculty House |
| Rembert Church |
| Republic Theater |
| Retreat Rosenwald School |
| Richardson-Godbold House |
| Richardson, J.C., House |
| Richardson, Lawrence L., House |
| Richland Cemetery |
| Ridge Hill High School |
| Ridgeway Historic District |
| Robb, William, House |
| Robert Mills Manor |
| Robinson-Hiller House |
| Rock Hill Body Company |
| Rock Hill Cotton Factory |
| Rock Hill Downtown Historic District |
| Rock Hill Printing and Finishing Company |
| Rockville Historic District |
| Rogers, Paul H., House |
| Rogers, William, House |
| Roselawn |
| Rosemary Hall |
| Roseville Plantation |
| Ruffin High and Elementary School |
| Ruff's Chapel |
| Russell-Heath House |
| Ruth's Beauty Parlor |
| Sadler Store |
| Salley Historic District |
| Salmon, George, House |
| Salters Plantation House |
| Saluda Apartments |
| Saluda Theatre |
| Sandy Island School |
| Scarborough, Henry Lee, House |
| Scheper, F.W., Store |
| Schuyler Apartments |
| Scott House |
| Seaboard Air Line Railway Depot |
| Seaboard Air Line Railway Depot in McBee |
| Seaboard Air Line Railway Depot in Patrick |
| Seabrook, John, Plantation Bridge |
| Seacoast Packing Company |
| Seashore Farmers' Lodge No. 767 |
| Seaside Plantation House |
| Seaside School |
| Seay, Jammie, House |
| Self, James C., House |
| Selkirk Farm |
| Seneca Cotton Mill |
| Seneca Historic District |
| Senn's Grist Mill-Blacksmith Shop-Orange Crush Bottling Plant |
| Settlemyer House |
| Sharon Downtown Historic District |
| Shirley, Obediah, House |
| Sidney Park Colored Methodist Episcopal Church |
| Siloam School |
| Simmons-Harth House |
| Simmons, James Stocker, House |
| Simpsonville Baptist Church |
| Simpson, William Dunlap, House |
| Sims High School |
| Sinclair Service Station |
| Sitgreaves House |
| Sixth Naval District Training Aids Library |
| Slave Houses, Gregg Plantation |
| Smalls, Robert, School |
| Smith, J. Warren, House |
| Smith's Tavern |
| Smyrna Baptist Church |
| Socastee Historic District |
| Sottile, Giovanni, House |
| South Carolina Western Railway Station |
| Southern Bleachery and Print Works |
| Southern Cotton Oil Company |
| Southern Railway Depot |
| Southern Railway Depot |
| Southern Railway Passenger Station |
| South Harper Historic District |
Data from United States Park Service and Wikidata
