South Carolina - Significance region: Local
| Brooklands Plantation |
| Brooks, J. Wesley, House |
| Brown, Dianna, Antique Shop |
| Bruce, Donald, House |
| Brushy Creek |
| Burdette Building |
| Burroughs, Arthur M., House |
| Burroughs School |
| Bush House |
| Cainhoy Historic District |
| Caldwell-Johnson-Morris Cottage |
| Calhoun County Library |
| Calhoun-Gibert House |
| Calhoun, John C., State Office Building |
| Calhoun Mill |
| Campbell Chapel AME Church |
| Camp Hill |
| Cannon Building |
| Cannon, W. E., House and Store |
| Cantey, Zachariah, House |
| Carnegie Free Library |
| Carnegie Public Library |
| Carnes, James, House |
| Carolina Life Insurance Company |
| Carolina Supply Company |
| Carroll Place |
| Carroll Rosenwald School |
| Carter Hill |
| Cartledge House |
| Carver Theatre |
| Cashua Street-Spring Street Historic District |
| Cassina Point |
| Catawba Rosenwald School |
| Catfish Creek Baptist Church |
| Cattle Mound #6 |
| Cayce, William J., House |
| Cedar Bluff |
| Cedar Grove Lutheran Church |
| Cedar Grove Plantation Chapel |
| Cedars, The |
| Central Baptist Church |
| Central Graded School |
| Central High School |
| Central Methodist Church |
| Central Roller Mills |
| Century House |
| Chamberlain-Kay House |
| Chamber of Commerce Building |
| Champion and Pearson Funeral Home |
| Chapin Commercial Historic District |
| Chappell House |
| Charleston Cemeteries Historic District |
| Charleston Consolidated Railway, Electric and Gas Company Car House |
| Charleston Naval Hospital |
| Charlotte Avenue-Aiken Avenue Historic District |
| Charlton Hall Plantation House |
| Cherry Hill School |
| Chester City Hall and Opera House |
| Chinaberry |
| Christ Church |
| Christ Church (Episcopal) and Churchyard |
| Christ Episcopal Church |
| Church of the Advent |
| Church of the Holy Apostles, Episcopal |
| Church of the Holy Apostles Rectory |
| Church Street Historic District |
| Cigar Factory |
| Citadel Shirt Corporation |
| Clarendon County Health Center and Office Building |
| Clarkson Farm Complex |
| Claussen House |
| Claussen's Bakery |
| Cleveland Law Range |
| Clinton Chapel AME Zion Church |
| Clinton Commercial Historic District |
| Clover Downtown Historic District |
| Cockfield, P.D., House |
| Coffin Point Plantation |
| Cohasset |
| Coker, J. L., Company Building |
| Coker, Robert R., House |
| Coker, S. Pressly, House |
| Coker Spring |
| Colding-Walker House |
| Colonial-Hites Company |
| Colonial Village Apartments |
| Columbia Central Fire Station |
| Columbia Electric Street Railway, Light & Power Substation |
| Columbia Township Auditorium |
| Colvin-Fant-Durham Farm Complex |
| Commercial Hotel |
| Converse Heights Historic District |
| Converse Mill |
| Conway Downtown Historic District |
| Conway Methodist Church, 1898 and 1910 Sanctuaries |
| Conway Post Office |
| Conway Residential Historic District |
| Cook's Lake Cattle Mound |
| Cook's Old Field Cemetery |
| Cooner's Cattle Mound |
Data from United States Park Service and Wikidata
