South Carolina - Significance region: Local
| Cope Depot |
| Copeland House |
| Corley, C. E., House |
| Cornell Arms |
| Cornwell, Harriet M., Tourist House |
| Cornwell Inn |
| Coulter Memorial Academy Historic District |
| Court Tennis Building |
| Cowpens Depot |
| Crawford's Plantation House |
| Crossways |
| Culclasure-Geiger Farmstead |
| Culp House |
| Cureton House |
| Cureton-Huff House |
| Cuthbert, John A., House |
| Dantzler, Col. Olin M., House |
| Dantzler Plantation |
| Dargan, Julius A., House |
| Darlington Downtown Historic District |
| Darlington Industrial Historic District |
| Darlington, Lyde Irby, House |
| Darlington Memorial Cemetery |
| Darlington Theatre |
| Davenport Apartments |
| Davenport House |
| Davidson Hall, Coker College |
| Davis House |
| Davis, James M., House |
| Davis Plantation |
| Davis, Winnie, Hall |
| Dawkins, Judge Thomas, House |
| Dawson-Vanderhorst House |
| Dead River Cattle Mound |
| Dead River Dike |
| Deas, Edmund H., House |
| Debruhl-Marshall House |
| Denmark High School |
| Dennis High School |
| Denver Downs Farmstead |
| Derham, John P., House |
| Dial, Allen, House |
| Dillard Barn |
| Dillon Downtown Historic District |
| Dillon Graded School and Dillon Public School |
| Dillon, James W., House |
| Dixie Library Building |
| Donalds Grange No. 497 |
| Donaldson, T. Q., House |
| Dorn Gold Mine |
| Dorn, Joseph Jennings, House |
| Dorn's Flour and Grist Mill |
| Dove Dale |
| Downtown Baptist Church |
| Drayton Mill |
| Dreher, Jacob Wingard, House |
| Duckett, Charles H., House |
| Duncan, Bishop William Wallace, House |
| Duncan Park Stadium |
| Duncan's Creek Presbyterian Church |
| Dunean Mill Historic District |
| Dunklin, James, House |
| Earle, Col. Elias, Historic District |
| Easley High School Auditorium |
| Easley Mill |
| East Main Street Historic District |
| East Park Historic District |
| Ebenezer Academy |
| Ebony Guest House |
| Eden Hall |
| Edgefield Cotton Mill-Addison Mill |
| Edgewood School |
| Edwards, Broadus, House |
| Efird's Department Store |
| Ellen Dean Hotel |
| Ellerbe's Mill |
| Elliott House |
| Ellis Avenue Historic District |
| Ellison Flour Mill |
| Elmwood Cemetery |
| Elmwood Park Historic District |
| Emanuel African Methodist Episcopal Church |
| Engineering-Management Building |
| English, Thomas, House |
| Enterprise Cotton Mills Building |
| Episcopal Church of the Nativity |
| Epps-McGill Farmhouse |
| Erwin House |
| Evans, Frank, High School |
| Evins-Bivings House |
| Faber House |
| Fair Forest Hotel |
| Fairview Presbyterian Church |
| Farmer's Bank |
| Farmfield Plantation House |
| Federal Land Bank Building |
| Fennell, Dr. W.W. and Mary, House |
| Finley High School |
| First Baptist Church |
| First National Bank |
Data from United States Park Service and Wikidata
