South Carolina - Significance region: Local
| Abbeville County Training School |
| Abbeville Opera House |
| Afro-American Insurance Company Building |
| Aiken Colored Cemetery |
| Aiken County Hospital |
| Aiken, Hugh, House |
| Aiken Winter Colony Historic District I |
| Aiken Winter Colony Historic District II |
| Aiken Winter Colony Historic District III |
| Albright-Dukes House |
| Alderman's 20 Stores in One |
| Alexander-Hill House |
| Alexander House |
| Allendale County Courthouse |
| Allendale Training School |
| Allen, Joel, House |
| Allen Temple A.M.E. Church |
| All Saints' Episcopal Church, Waccamaw |
| Alta Vista-Camp Fornance-Newman Park Historic District |
| Ambrose, H. W., House |
| Amelia Street Historic District |
| American Cigar Factory |
| American Legion Building |
| American Legion Hut |
| American Spinning Company Mill No. 2 |
| American Telephone and Telegraph Company Building |
| Anchorage, The |
| Anderson College Historic District |
| Anderson Historic District |
| Anderson's Mill |
| Apalache Mill |
| Appin |
| Appleby's Methodist Church |
| Arcade Building |
| Arcade Hotel |
| Arcadia Mill No.1 |
| Arcadia Mill No. 2 |
| Arial Mill |
| Ashley-Willis House |
| Ashtabula |
| Ashwood School Gymnasium and Auditorium |
| Askins, W. T., House |
| Atlantic Coast Line Railroad Depot |
| Atlanticville Historic District |
| Bailey's Store |
| Baker, William, House |
| Ballentine-Shealy House |
| Bamberg City Hall |
| Bamberg Post Office |
| Bank of Hampton |
| Bank of Western Carolina |
| Banks, Col. J. A., House |
| Banksia Hall |
| Banks-Mack House |
| Barnwell, Arthur, House |
| Barnwell House |
| Barnwell, William, House |
| Barr, D. D. D., House |
| Batesburg Commercial Historic District |
| Beattie, Fountain Fox, House |
| Beaty-Little House |
| Beaty-Spivey House |
| Bedenbaugh, Jacob, House |
| Bellevue-Newman's Field-Gracelynn Terrace Historic District |
| Belton Depot |
| Bennett, Gov. Thomas, House |
| Bennettsville Historic District |
| Berly, William, House |
| Berly, W. Q. M., House |
| Bethea, Alpheus Victor and Martha Cooper, Farmstead |
| Bethel African Methodist Episcopal Church |
| Bethel A.M.E. Church |
| Bethel Methodist Church |
| Bethel Presbyterian Church |
| Bethesda Presbyterian Church |
| Beth Israel Synagogue |
| Bethlehem Baptist Church |
| Bettis Academy and Junior College |
| Beverly Apartments |
| Big Lake Cattle Mound |
| Bishopville Commercial Historic District |
| Bivings-Converse House |
| Black River Plantation House |
| Blake Tenements |
| Bleachery Water Treatment Plant |
| Bleak Hall Plantation Outbuildings |
| Blink Bonnie |
| Blooming Grove |
| Bluffton Historic District |
| Bob Russell Realty Building |
| Bonham House |
| Bonnie Shade |
| Boone-Douthit House |
| Boozer, Lemuel, House |
| Borden Ice Cream Factory |
| Bouknight, Simon, House |
| Brady's Cattle Mound |
| Brandon Mill |
| Briggman, F. H. W., House |
| Brogdon, J. Clinton, House |
Data from United States Park Service and Wikidata
