South Carolina - Area of significance: Industry
| American Spinning Company Mill No. 2 |
| Anderson House |
| Anderson's Mill |
| Apalache Mill |
| Arcadia Mill No.1 |
| Arcadia Mill No. 2 |
| Arial Mill |
| Arsenal Hill |
| Ashtabula |
| Bates, William, House |
| Belle Isle Rice Mill Chimney |
| Bennett, Gov. Thomas, House |
| Bishopville Commercial Historic District |
| Bleachery Water Treatment Plant |
| Borden Ice Cream Factory |
| Boundary Street-Newberry Cotton Mills Historic District |
| Boykin Mill Complex |
| Brandon Mill |
| Buchan, A. H., Company Building |
| Buck's Upper Mill Farm |
| Buffalo Mill Historic District |
| Calhoun Mill |
| Callawassie Sugar Works |
| Central Roller Mills |
| Chicora Wood Plantation |
| Cigar Factory |
| Claussen's Bakery |
| Coker, James L., III, House |
| Coker, Robert R., House |
| Colonial-Hites Company |
| Columbia Canal |
| Columbia Historic District I |
| Columbia Mills Building |
| Confederate Printing Plant |
| Converse Mill |
| Coopersville Ironworks Site (38CK2) and Susan Furnace Site (38CK67) |
| Cowpens Furnace Site (38CK73) |
| Darlington Industrial Historic District |
| Dorn Gold Mine |
| Dorn's Flour and Grist Mill |
| Drayton Mill |
| Dunean Mill Historic District |
| Dunlap, C. K., House |
| Earle Town House |
| Early Cotton Press |
| Easley Mill |
| East Home Avenue Historic District |
| Edgefield Cotton Mill-Addison Mill |
| Ellen Furnace Site (38CK68) |
| Ellerbe's Mill |
| Ellison Flour Mill |
| Enterprise Cotton Mills Building |
| Evins-Bivings House |
| Fairfield Rice Mill Chimney |
| Fair-Rutherford and Rutherford Houses |
| Fort Lyttelton Site |
| Fort Mill Manufacturing Company Mill No. 2 |
| Friendfield Plantation |
| General Asbestos and Rubber Company (GARCO) Main Mill |
| Gilbert, J. B., House |
| Gilreath's Mill |
| Goodwill Plantation |
| Granby Mill Village Historic District |
| Graniteville Historic District |
| Great Falls Depot |
| Greenville Gas and Electric Light Company |
| Greenville Pepsi-Cola Bottling Plant |
| Greer Mill |
| Guignard Brick Works |
| Hagood Mill |
| Hickman Mill Historic District |
| Highland Park Manufacturing Plant and Cotton Oil Complex |
| Imperial Tobacco Company Building |
| Inman Mills |
| Irene Mill Finishing Plant |
| Isaqueena |
| Jackson's Furnace Site (38YK217) |
| Judson Mill |
| Kendall Mill Historic District |
| Kincaid-Anderson House |
| King's Creek Furnace Site (38CK71) |
| Koon, John Jacob Calhoun, Farmstead |
| Lancaster Cotton Oil Company |
| Liberty Warehouse |
| Limestone Springs Historic District |
| Lucas, Jonathan, House |
| Manor, The |
| McCorkle-Fewell-Long House |
| Medway |
| Merridun |
| Milldam Rice Mill and Rice Barn |
| Mills Mill |
| Monaghan Mill |
| Nesbitt's Limestone Quarry (38CK69) |
| New Brookland Historic District |
| Newry Historic District |
| Nightingale Hall Rice Mill Chimney |
| Old Market Building |
| Olympia Mill |
| Olympia Mill Village Historic District |
Data from United States Park Service and Wikidata
