South Carolina - Area of significance: Industry
| Olympia Union Hall |
| Orangeburg Downtown Historic District |
| Orr, Dr. Samuel Marshall, House |
| Otranto Plantation Indigo Vats |
| Pacolet Mills Cloth Room and Warehouse |
| Pacolet Mills Historic District |
| Palmetto Compress and Warehouse Company Building |
| Parker High School Auditorium |
| Pee Dee River Rice Planters Historic District |
| Pelham Mills Site (38GR165) |
| Pelzer Manufacturing Company and Mill Village Historic District |
| Pendleton Cotton Mill |
| Pendleton Historic District |
| Poe Hardware and Supply Company |
| Pottersville |
| Price's Mill |
| Reedy River Falls Historic Park and Greenway |
| Reedy River Industrial District |
| Republic Theater |
| Richland Cotton Mill |
| Robb, William, House |
| Rock Hill Body Company |
| Rock Hill Cotton Factory |
| Rock Hill Printing and Finishing Company |
| Rockton and Rion Railroad Historic District |
| Rogers, Paul H., House |
| Saluda Factory Historic District |
| Seacoast Packing Company |
| Self, James C., House |
| Seneca Cotton Mill |
| Sheriff Mill Complex |
| Shivar Springs Bottling Company Cisterns |
| Smith Barn |
| Southern Bleachery and Print Works |
| Southern Cotton Oil Company |
| South Harper Historic District |
| Springfield Plantation House |
| Springs, Leroy, House |
| Standard Oil Company Headquarters |
| Startex Finishing Company |
| Stone Manufacturing Company |
| Stony Point |
| Thicketty Mountain Ore Pits (38CK74) |
| Trapp and Chandler Pottery Site (38GN169) |
| Triangle Building |
| Union Downtown Historic District |
| Vaucluse Mill Village Historic District |
| Ware Shoals Inn |
| Warren Mill |
| Weehaw Rice Mill Chimney |
| West Gervais Street Historic District |
| West Point Rice Mill |
| White, William Elliott, House |
| Woodside Cotton Mill Village Historic District |
Data from United States Park Service and Wikidata
