South Carolina - Area of significance: Commerce
| Abbeville Historic District |
| Afro-American Insurance Company Building |
| Alderman's 20 Stores in One |
| Alston House |
| American Cigar Factory |
| Anderson Downtown Historic District |
| Arcade Hotel |
| Arcadia Mill No. 2 |
| Atlantic Coast Line Railroad Depot |
| Bache, Alexander, U.S. Coast Survey Line |
| Bailey's Store |
| Bank of Hampton |
| Bank of Western Carolina |
| Batesburg Commercial Historic District |
| Beaufort Historic District |
| Bennett, Gov. Thomas, House |
| Bishopville Commercial Historic District |
| Bluffton Historic District |
| Boykin Mill Complex |
| BROWN'S FERRY VESSEL |
| Brushy Creek |
| Building at 1644 Main Street |
| Burdette Building |
| Burroughs, Arthur M., House |
| Byrd, J. A., Mercantile Store |
| Cannon Building |
| Cannon, W. E., House and Store |
| Carnes, James, House |
| Carolina Supply Company |
| Cedar Bluff |
| Chapin Commercial Historic District |
| Charleston's French Quarter District |
| Cheraw Historic District |
| Chester Historic District |
| Citizens and Southern National Bank of South Carolina |
| Clarkson Farm Complex |
| Claussen's Bakery |
| Clinton Commercial Historic District |
| Clio Historic District |
| Clover Downtown Historic District |
| Coker, J. L., Company Building |
| Columbia Canal |
| Commercial Hotel |
| Confederate Printing Plant |
| """Congarees"" Site" |
| Conway Downtown Historic District |
| Corner Packing Shed, The |
| Darlington Downtown Historic District |
| Davis, James M., House |
| Debruhl-Marshall House |
| Dillon, James W., House |
| Dorn, Joseph Jennings, House |
| Dorn's Flour and Grist Mill |
| Duckett, Charles H., House |
| East Main Street Historic District |
| Edgefield Historic District |
| Efird's Department Store |
| Ellen Dean Hotel |
| Ellerbe's Mill |
| Ensor-Keenan House |
| Exchange and Provost |
| Fair Forest Hotel |
| Farmers and Merchants Bank Building |
| Farmer's Bank |
| Federal Land Bank Building |
| First National Bank |
| Five Points Historic District |
| Florence Downtown Historic District |
| Fort Mill Downtown Historic District |
| Fort Moore-Savano Town Site |
| Frogmore Plantation Complex |
| Gaffney Commercial Historic District |
| Georgetown Historic District |
| Gilreath's Mill |
| Gray Court Downtown Historic District |
| Great Falls Downtown Historic District |
| Green's Funeral Home and Ambulance Service |
| Greer Depot |
| Griffin Motor Company |
| Hampton Hendrix Office |
| Hendrix, Henry Franklin, House |
| Hester Store |
| Hill Complex Historic District |
| Holly Hill Downtown Historic District |
| Holman, J. B., House |
| Home National Bank |
| Hotel Albert Commercial Block |
| Hotel Eutaw |
| Hotel Oregon |
| Hunting Island State Park Lighthouse |
| Isaqueena |
| Keller Site |
| Kingstree Historic District |
| Kirkland, B. B., Seed and Distributing Company |
| Lancaster Downtown Historic District |
| Latta Downtown Historic District |
| Manne Building |
| Market Hall and Sheds |
| McGhee Block |
| McMakin's Tavern |
Data from United States Park Service and Wikidata
