South Carolina - Area of significance: Commerce
| McNair, A. M., House |
| Middleton Place |
| Miller Brothers Cotton Warehouse |
| Monaghan Mill |
| Montgomery Building |
| Montgomery, E.W., Cotton Warehouse |
| Montgomery, Walter Scott, House |
| Monticello Store and Post Office |
| Morgan House |
| Mount Pleasant Historic District |
| Myrtle Beach Downtown Historic District |
| Neal and Dixon's Warehouse |
| New Brookland Historic District |
| Nicholson, James, House |
| Ninety Six National Historic Site |
| North Carolina Mutual Building |
| Old Dorchester |
| Old Market Building |
| Orangeburg Downtown Historic District |
| Orr, Dr. Samuel Marshall, House |
| Pendleton Historic District |
| People's National Bank Building |
| Piedmont Mill Stores Building |
| Price's Mill |
| Price's Post Office |
| Pritchard, Paul, Shipyard |
| Ram Cat Alley Historic District |
| Rasor and Clardy Company Building |
| Reedy River Industrial District |
| Ridgeway Historic District |
| Robinson-Hiller House |
| Rock Hill Downtown Historic District |
| Rogers, William, House |
| Ruff's Chapel |
| Salley Historic District |
| Saluda Factory Historic District |
| Santee Canal |
| Scheper, F.W., Store |
| Seabrook, John, Plantation Bridge |
| Senn's Grist Mill-Blacksmith Shop-Orange Crush Bottling Plant |
| Sharon Downtown Historic District |
| Silver Bluff |
| Sixth Naval District Training Aids Library |
| Smith Barn |
| Socastee Historic District |
| South Carolina National Bank of Charleston |
| Southern Railway Passenger Depot |
| South Harper Historic District |
| Spartanburg Historic District |
| Spencer House |
| Springfield Plantation House |
| Stumphouse Tunnel Complex |
| Sturkey, M. L. B., House |
| Sumter Historic District |
| Taylor House |
| Tennent, Josiah Smith, House |
| Townsend's, Hephzibah Jenkins, Tabby Oven Ruins |
| Triangle Building |
| Union Downtown Historic District |
| Union National Bank Building |
| U.S. Customhouse |
| Waccamaw River Warehouse Historic District |
| West End Commercial Historic District |
| West Gervais Street Historic District |
| Whaley, W. B. Smith, House |
| White Oak Historic District |
| Willtown Bluff |
| Winnsboro Historic District |
| Woodrow Memorial Presbyterian Church |
| York Historic District |
Data from United States Park Service and Wikidata
