South Carolina - Area of significance: Black Heritage
| Abbeville County Training School |
| Afro-American Insurance Company Building |
| Aiken Colored Cemetery |
| Allendale Training School |
| Allen University |
| All Star Bowling Lane |
| Alston House |
| Atlantic Beach Historic District |
| Bailey, Dr. York, House |
| Barber House |
| Beaufort Historic District |
| Benedict College Historic District |
| Benson, Florence C., Elementary School |
| Bethel African Methodist Episcopal Church |
| Bethlehem Baptist Church |
| Bettis Academy and Junior College |
| Brown, Dianna, Antique Shop |
| Cainhoy Historic District |
| Campbell Chapel AME Church |
| Camp Saxton Site |
| Camp Welfare |
| Carroll Rosenwald School |
| Carver Theatre |
| Catawba Rosenwald School |
| Cedar Grove Plantation Chapel |
| Central Baptist Church |
| Champion and Pearson Funeral Home |
| Cheraw Historic District |
| Cherry Hill School |
| Claflin College Historic District |
| Clinton AME Zion Church |
| Clinton Chapel AME Zion Church |
| Coffin Point Plantation |
| Columbia Township Auditorium |
| Corinth Baptist Church |
| Cornwell, Harriet M., Tourist House |
| Coulter Memorial Academy Historic District |
| Darlington Memorial Cemetery |
| Daufuskie Island Historic District |
| Deas, Edmund H., House |
| Dennis High School |
| Duckett, Charles H., House |
| Dukes Gymnasium |
| East Russell Street Area Historic District |
| Ebony Guest House |
| Eddings Point Community Praise House |
| Edgewood School |
| Edisto Island Baptist Church |
| Emanuel African Methodist Episcopal Church |
| Epps-McGill Farmhouse |
| Evans, Dr. Matilda A., House |
| Faber House |
| Fair-Rutherford and Rutherford Houses |
| Faith Cabin Library at Anderson County Training School |
| Faith Cabin Library at Seneca Junior College |
| Finley High School |
| Fish Haul Archaeological Site (38BU805) |
| Fordham, Maj. John Hammond, House |
| Fountain Inn Principal's House and Teacherage |
| Friendfield Plantation |
| Frogmore Plantation Complex |
| Gallman High School |
| Gifford Rosenwald School |
| Good Samaritan-Waverly Hospital |
| Goodwill Plantation |
| Great Branch Teacherage |
| Green's Funeral Home and Ambulance Service |
| Green, The |
| Gregg-Wallace Farm Tenant House |
| Hampton Colored School |
| Hampton-Pinckney Historic District |
| Hannah Rosenwald School |
| Harbison College President's Home |
| Harden Street Substation |
| Hebron Presbyterian Church |
| Hermon Presbyterian Church |
| Hobcaw Barony |
| Hodge Hall |
| Holly Springs School |
| Holman’s Barber Shop |
| Holy Cross Faith Memorial School |
| Hopewell Rosenwald School |
| Hutchinson House |
| Immanuel School |
| Jamestown Historic District |
| Jenkins, Mary, Community Praise House |
| Keithfield Plantation |
| King Cemetery |
| Knights of Wise Men Lodge |
| Kumler Hall |
| Ladson Presbyterian Church |
| Latimer High and Elementary School |
| Leevy’s Funeral Home |
| Lowman Hall, South Carolina State College |
| Magnolia |
| Mann-Simons Cottage |
| Marlboro County Training School |
| Marysville School |
| Maude Callen Clinic |
| McCollum-Murray House |
Data from United States Park Service and Wikidata
