South Carolina - Area of significance: Architecture
| Robb, William, House |
| Robert Mills Manor |
| Robertson-Easterling-McLaurin House |
| Robertson, William, House |
| Robertville Baptist Church |
| Robinson-Hiller House |
| Rock Hill Cotton Factory |
| Rock Hill Downtown Historic District |
| Rockville Historic District |
| Rogers, Paul H., House |
| Rogers, William, House |
| Roper House Complex |
| Roper, Robert William, House |
| Rose Hill |
| Rose Hill Plantation House |
| Roselawn |
| Rosemary Hall |
| Rose, Thomas, House |
| Roseville Plantation |
| Ruffin High and Elementary School |
| Ruff's Chapel |
| Rural Hall Plantation House |
| Rural Point |
| Russell-Heath House |
| Russell House |
| Russell, Nathaniel, House |
| Saint Thomas' Protestant Episcopal Church |
| Salem Black River Presbyterian Church |
| Salley Historic District |
| Salmon, George, House |
| Salters Plantation House |
| Saluda Apartments |
| Saluda Theatre |
| Sams Plantation Complex Tabby Ruins |
| Sandy Island School |
| Sapp, William Harrison, House |
| Scarborough, Henry Lee, House |
| Schuyler Apartments |
| Scott, Claudius, Cottage |
| Scott House |
| Seaboard Air Line Railway Depot |
| Seaboard Air Line Railway Depot in McBee |
| Seaboard Air Line Railway Depot in Patrick |
| Seabrook, William, House |
| Seacoast Packing Company |
| Seaside Plantation |
| Seaside Plantation House |
| Seay, Jammie, House |
| Secessionville Historic District |
| Self, James C., House |
| Selkirk Farm |
| Seneca Historic District |
| Settlemyer House |
| Sharon Downtown Historic District |
| Sheldon Church Ruins |
| Sheriff Mill Complex |
| Shiloh Methodist Church |
| Shirley, Obediah, House |
| Sidney Park Colored Methodist Episcopal Church |
| Simmons-Edwards House |
| Simmons-Harth House |
| Simmons, Robert, House |
| Simpsonville Baptist Church |
| Simpson, William Dunlap, House |
| Sinclair Service Station |
| Sitgreaves House |
| Slave Houses, Gregg Plantation |
| Slave Street, Smokehouse, and Allee, Boone Hall Plantation |
| Smalls, Robert, School |
| Smith Barn |
| Smith-Cannon House |
| Smith, J. Warren, House |
| Smith's Tavern |
| Smyrna Baptist Church |
| Snee Farm-Charles Pinckney National Historic Site |
| Socastee Historic District |
| South Carolina Archives Building |
| South Carolina Governor's Mansion |
| South Carolina National Bank of Charleston |
| South Carolina State Armory |
| South Carolina State Arsenal |
| South Carolina State College Historic District |
| South Carolina State Hospital, Mills Building |
| South Carolina Statehouse |
| South Carolina State Library |
| South Carolina Western Railway Station |
| Southern Railway Depot |
| South Harper Historic District |
| South Main Historic District |
| South Street-South Church Street Historic District |
| Spann Methodist Church and Cemetery |
| Sparrow, James, House |
| Spartanburg Historic District |
| Spencer House |
| Spigner, A. Fletcher, House |
| Springfield High School |
| Springfield Plantation House |
| Springs, Leroy, House |
| Spring Street Methodist Church |
| Standard Oil Company Headquarters |
Data from United States Park Service and Wikidata
