South Carolina - Area of significance: Architecture
| St. Andrew's Episcopal Church |
| St. Andrews Episcopal Church |
| Stateburg Historic District |
| St. David's Episcopal Church and Cemetery |
| Stevens-Dorn Farmstead |
| Stewart, James, House |
| St. George Rosenwald School |
| St. Helena Parish Chapel of Ease Ruins |
| Stiles-Hinson House |
| Still Hopes |
| St. James' Church, Goose Creek |
| St. James Episcopal Church, Santee |
| St. James the Greater Catholic Mission |
| St. John's Historic District |
| St. John's Lutheran Church |
| St. John's Lutheran Church |
| St. Julien Plantation |
| St. Luke's Church |
| St. Mark's Church |
| St. Mary Help of Christians Church |
| St. Mary's Roman Catholic Church |
| St. Michael's Episcopal Church |
| St. Michael's Evangelical Lutheran Church |
| Stokes-Mayfield House |
| Stoney-Baynard Plantation |
| Stoney Creek Independent Presbyterian Chapel of Prince William Parish |
| Stony Point |
| St. Paul Camp Ground |
| St. Paul's Methodist Church |
| St. Peter's Roman Catholic Church |
| St. Philip's Episcopal Church |
| St. Philip's Episcopal Church, Bradford Springs |
| Strawberry Chapel and Childsbury Town Site |
| Stribling, J.C., Barn |
| Stroman, William P., House |
| Strother Place, Old |
| Structural Science Building |
| St. Stephen's Episcopal Church |
| St. Stephen's Episcopal Church |
| Stuart, Col. John, House |
| Sturgis, R.L. and Annie, House |
| Sturkey, M. L. B., House |
| Sullivan House |
| Sullivan's Island Historic District |
| Summer Brothers Stores |
| Summer Chapel, Prince Frederick's Episcopal Church |
| Summer Chapel Rectory, Prince Frederick's Episcopal Church |
| Summerville Historic District |
| Summit Plantation House |
| Sumter County Courthouse |
| Sumter Historic District |
| Sumter Town Hall-Opera House |
| Sun Fun Motel |
| Sunnyside |
| Sunnyside |
| Supreme Court of South Carolina Building |
| Sword Gate Houses |
| Sylvan Building |
| Sylvania |
| Tabby Manse |
| Table Rock Civilian Conservation Corps Camp Site |
| Table Rock State Park Historic District |
| Tall Oaks |
| Taveau Church |
| Tawana Motel |
| Taylor, Earle R., House and Peach Packing Shed |
| Taylor House |
| Temple Sinai |
| Tennent, Josiah Smith, House |
| The Oaks |
| The Oaks |
| Thorntree |
| Thornwell-Elliott House |
| Thornwell-Presbyterian College Historic District |
| Thurmond, Strom, Federal Building and U.S. Courthouse |
| Tillman Hall |
| Tillman School |
| Timberhouse |
| Tingley Memorial Hall, Claflin College |
| Tocaland |
| Tombee Plantation |
| Towles Farmstead |
| Town Theatre |
| Treadwell Street Historic District |
| Trinity Episcopal Church |
| Trinity Episcopal Church |
| Trinity Episcopal Church and Cemetery |
| Trinity Lutheran Church |
| Trinity Methodist Episcopal Church |
| Tullyton |
| Turner, Robert G., House |
| Turner, R. Perry, House |
| Ulmer-Summers House |
| Union Church of Port Royal |
| Union County Jail |
| Union Downtown Historic District |
| Union High School-Main Street Grammar School |
| Union National Bank Building |
| Union Station |
| Unitarian Church |
Data from United States Park Service and Wikidata
