South Carolina - Area of significance: Architecture
| Latta Historic District No. 1 |
| Latta Historic District No. 2 |
| Laurelwood |
| Laurens County Courthouse |
| Laurens Historic District |
| Lawson's Pond Plantation |
| Lawton, John, House |
| Lawton Park and Pavilion |
| Lawton-Seabrook Cemetery |
| Lawtonville Baptist Church |
| Lee County Courthouse |
| Leesville College Historic District |
| Lemmon, Bob, House |
| Lever Building |
| Lewisfield Plantation |
| Lewis Inn |
| Lexington County Courthouse |
| Liberty Hill Historic District |
| Lide, Evan J., House |
| Lide, John W., House |
| Little Mountain Historic District |
| Little River Baptist Church |
| Loch Dhu |
| Logan School |
| Lookaway Hall |
| Lorick, Preston C., House |
| Lower Long Cane Associate Reformed Presbyterian Church |
| Lowman Hall, South Carolina State College |
| Lowndes Grove |
| Lucas, Dr. Thomas E., House |
| Lucas, Jonathan, House |
| Lutheran Theological Seminary Building: Beam Dormitory |
| Lybrand, Henry, Farm |
| Lydia Plantation |
| Lyles-Gudmundson House |
| Lynchburg Presbyterian Church |
| Mack-Belk House |
| Magness-Humphries House |
| Magnolia |
| Magnolia |
| Magnolia Cemetery |
| Magnolia Hall |
| Main Street Historic District |
| Manigault, Joseph, House |
| Manne Building |
| Manning Commercial Historic District |
| Manning Library |
| Manor, The |
| Mansfield Plantation |
| Manship Farmstead |
| Marine Barracks, Charleston Navy Yard |
| Marion High School |
| Marion Historic District |
| Marion Street Area Historic District |
| Market Hall and Sheds |
| Marshfield |
| Marsh-Johnson House |
| Marshlands |
| Marshlands Plantation House |
| Mason, Charles T., House |
| Massey-Doby-Nisbet House |
| Matson Street Historic District |
| Mayesville Historic District |
| Mayfair |
| McBee Methodist Church |
| McBride's Office Supply |
| McCall, Clarence, House |
| McClellanville Historic District |
| McCollum-Murray House |
| McCord House |
| McCorkle-Fewell-Long House |
| McCormick County Courthouse |
| McCormick County Office Building |
| McCormick Train Station |
| McCoy, Benjamin, House |
| McCoy Farmstead |
| McCrady's Tavern and Long Room |
| McCullough, Charles S., House |
| McDowell House |
| McGhee Block |
| McLaurin House |
| McLaurin-Roper-McColl Farmstead |
| McLeod Farmstead |
| McLeod Plantation |
| McMakin's Tavern |
| McMaster School |
| McMillan House |
| McNair, A. M., House |
| McPhail Angus Farm |
| McWhirter House |
| Means-Gage House |
| Means House |
| Medway |
| Meekins Barn |
| Meetze, Maj. Henry A., House |
| Meggett, W. Gresham, High and Elementary School |
| Melrose Heights-Oak Lawn-Fairview Historic District |
| Memorial Hall |
| Meng House |
| Merridun |
Data from United States Park Service and Wikidata
