South Carolina - Area of significance: Architecture
| Chicora Wood Plantation |
| Chinaberry |
| Christ Church |
| Christ Church (Episcopal) and Churchyard |
| Christ Episcopal Church |
| Church of the Advent |
| Church of the Cross |
| Church of the Holy Apostles, Episcopal |
| Church of the Holy Apostles Rectory |
| Church of the Holy Trinity |
| Church Street Historic District |
| Cigar Factory |
| Circular Congregational Church and Parish House |
| Citizens and Southern National Bank of South Carolina |
| City of Camden Historic District |
| Claflin College Historic District |
| Clarkson Farm Complex |
| Claussen House |
| Claussen's Bakery |
| Clemson College Sheep Barn |
| Clemson University Historic District I |
| Clemson University Historic District II |
| Cleveland Law Range |
| Clinton AME Zion Church |
| Clinton Commercial Historic District |
| Clio Historic District |
| Clover Downtown Historic District |
| Coateswood |
| Cockfield, P.D., House |
| Coffin Point Plantation |
| Coffin Point Plantation Caretaker's House |
| Cohasset |
| Coker, James L., III, House |
| Coker, J. L., Company Building |
| Coker, Robert R., House |
| Coker, S. Pressly, House |
| Colding-Walker House |
| College of Charleston |
| College Street Historic District |
| Colleton County Courthouse |
| Colonial Village Apartments |
| Columbia Central Fire Station |
| Columbia City Hall |
| Columbia Electric Street Railway, Light & Power Substation |
| Columbia Historic District I |
| Columbia Historic District II |
| Columbia Township Auditorium |
| Colvin-Fant-Durham Farm Complex |
| Commercial Hotel |
| Concord Presbyterian Church |
| Confederate Printing Plant |
| Consolidated Building |
| Converse College Historic District |
| Converse Heights Historic District |
| Converse Mill |
| Conway Downtown Historic District |
| Conway Methodist Church, 1898 and 1910 Sanctuaries |
| Conway Post Office |
| Conway Residential Historic District |
| Cool Springs |
| Cooper River Historic District |
| Copeland House |
| Corinth Baptist Church |
| Corley, C. E., House |
| Cornell Arms |
| Corner Packing Shed, The |
| Corner Store and Office, The |
| Cornwell Inn |
| Coulter Memorial Academy Historic District |
| Cousins House |
| Cowpens Depot |
| Craig House |
| Crawford's Plantation House |
| Cross Keys House |
| Crossways |
| Culclasure-Geiger Farmstead |
| Culp House |
| Cureton House |
| Cureton-Huff House |
| Curtiss-Wright Hangar |
| Cuthbert, John A., House |
| Cypress Methodist Camp Ground |
| Dantzler, Col. Olin M., House |
| Dantzler Plantation |
| Dargan, Julius A., House |
| Darlington Downtown Historic District |
| Darlington, Lyde Irby, House |
| Darlington Theatre |
| Daufuskie Island Historic District |
| Davenport Apartments |
| Davenport House |
| Davidson Hall, Coker College |
| Davis House |
| Davis Plantation |
| Davis, Winnie, Hall |
| Dawkins, Judge Thomas, House |
| Dawson-Vanderhorst House |
| Deas, Edmund H., House |
| Debruhl-Marshall House |
| Denmark High School |
Data from United States Park Service and Wikidata
