South Carolina - Area of significance: Architecture
| Denver Downs Farmstead |
| Derham, John P., House |
| Dial, Allen, House |
| Dillard Barn |
| Dillon County Courthouse |
| Dillon Downtown Historic District |
| Dillon Graded School and Dillon Public School |
| Dillon, James W., House |
| Dixie Library Building |
| Dock Street Theatre |
| Donalds Grange No. 497 |
| Donaldson, T. Q., House |
| Dorn, Joseph Jennings, House |
| Dorn's Flour and Grist Mill |
| Dove Dale |
| Dovillers-Manning-Magoffin House |
| Downtown Baptist Church |
| Drayton Hall |
| Drayton Mill |
| Dreher, Jacob Wingard, House |
| Duckett, Charles H., House |
| Dukes Gymnasium |
| Duncan, Bishop William Wallace, House |
| Duncan's Creek Presbyterian Church |
| Dunklin, James, House |
| Dunlap, C. K., House |
| Earle, Col. Elias, Historic District |
| Earle Town House |
| Easley High School Auditorium |
| Easley Mill |
| East Home Avenue Historic District |
| East Main Street-Douglass Heights Historic District |
| East Main Street Historic District |
| East Park Historic District |
| East Richland Street-East Church Street Historic District |
| East Russell Street Area Historic District |
| Eau Claire Town Hall and Survey Publishing Company Building |
| Ebenezer Associate Reformed Presbyterian Church |
| Ebenezer Lutheran Chapel |
| Eddings Point Community Praise House |
| Eden Hall |
| Edgefield Cotton Mill-Addison Mill |
| Edgefield Historic District |
| Edgewood School |
| Edisto Island Presbyterian Church |
| Edwards, Broadus, House |
| Ellerbe's Mill |
| Elliott House |
| Ellis Avenue Historic District |
| Elmwood Park Historic District |
| Engineering-Management Building |
| English, Thomas, House |
| Ensor-Keenan House |
| Enston, William, Home |
| Enterprise Cotton Mills Building |
| Episcopal Church of the Nativity |
| Epps-McGill Farmhouse |
| Erskine College-Due West Historic District |
| Erwin House |
| Evans, Frank, High School |
| Evans-Russell House |
| Evins-Bivings House |
| Exchange and Provost |
| Faber House |
| Fairfield Plantation |
| Fair Forest Hotel |
| Fairview Presbyterian Church |
| Farmers' and Exchange Bank |
| Farmers and Merchants Bank Building |
| Farmer's Bank |
| Farmfield Plantation House |
| Federal Land Bank Building |
| Fenwick Hall |
| Fig Island Site |
| Finley High School |
| Fireproof Building |
| First Baptist Church |
| First Baptist Church |
| First National Bank |
| First National Bank |
| First Presbyterian Church |
| First Presbyterian Church |
| First Presbyterian Church of Woodruff |
| Florence Crittenton Home |
| Florence Downtown Historic District |
| Florence Public Library |
| Folk-Holloway House |
| Fonti Flora Plantation |
| Fordham, Maj. John Hammond, House |
| Forest Hills Historic District |
| Fort Frederick |
| Fort Fremont Battery |
| Fort Fremont Hospital |
| Fort Lyttelton Site |
| Fort Mill Downtown Historic District |
| Fort Moultrie Quartermaster and Support Facilities Historic District |
| Fort Sumter National Monument |
| Foster's Tavern |
| Fountain Inn High School |
| Fowler, William Dixon, House |
Data from United States Park Service and Wikidata
