South Carolina - Area of significance: Architecture
| Black River Plantation House |
| Blake Tenements |
| Bleachery Water Treatment Plant |
| Bleak Hall Plantation Outbuildings |
| Blink Bonnie |
| Blocker House |
| Blooming Grove |
| Bluffton Historic District |
| Bob Russell Realty Building |
| Bonham House |
| Bonnie Shade |
| Boone-Douthit House |
| Boozer, Lemuel, House |
| Borough House Plantation |
| Bouknight, Simon, House |
| Boundary Street-Newberry Cotton Mills Historic District |
| Boykin Mill Complex |
| Branford-Horry House |
| Brattonsville Historic District |
| Brevard, Keziah Goodwyn Hopkins, House |
| Brewton, Miles, House |
| Brewton, Robert, House |
| Brice, Dr. Walter, House and Office |
| Brick House Ruin |
| Briggman, F. H. W., House |
| Broad Margin |
| Brogdon, J. Clinton, House |
| Brooklands Plantation |
| Brooks, J. Wesley, House |
| Browntown |
| Bruce, Donald, House |
| Brushy Creek |
| Buffalo Mill Historic District |
| Building at 1210-1214 Main Street |
| Building at 1644 Main Street |
| Building at 1722-1724 Main Street |
| Building at 303 Saluda Avenue |
| Burdette Building |
| Burroughs, Arthur M., House |
| Burt, Armistead, House |
| Burton House |
| Bush House |
| Byrd, J. A., Mercantile Store |
| Cainhoy Historic District |
| Caldwell-Hampton-Boylston House |
| Caldwell-Johnson-Morris Cottage |
| Caldwell Street Historic District |
| Calhoun County Courthouse |
| Calhoun County Library |
| Calhoun-Gibert House |
| Calhoun, John C., State Office Building |
| Calhoun Mill |
| Camp Hill |
| Canal Dime Savings Bank |
| Cannon, W. E., House and Store |
| Cantey, Zachariah, House |
| Carnegie Free Library |
| Carnegie Public Library |
| Carnes, James, House |
| Carolina Life Insurance Company |
| Carolina Supply Company |
| Carroll, Chancellor James P., House |
| Carroll Place |
| Carroll Rosenwald School |
| Carter Hill |
| Cartledge House |
| Cashua Street-Spring Street Historic District |
| Cassina Point |
| Catawba Rosenwald School |
| Catfish Creek Baptist Church |
| Catholic Presbyterian Church |
| Cauthen, Dr. William Columbus, House |
| Cedar Bluff |
| Cedar Grove |
| Cedar Grove Lutheran Church |
| Cedar Grove Plantation Chapel |
| Cedar Springs Historic District |
| Cedars, The |
| Central Baptist Church |
| Central Graded School |
| Central High School |
| Central Methodist Church |
| Century House |
| Chamberlain-Kay House |
| Chamber of Commerce Building |
| Chapelle Administration Building |
| Chappell House |
| Charleston Historic District |
| Charleston Historic District |
| Charleston Naval Hospital |
| Charleston Naval Hospital Historic District |
| Charleston Navy Yard Historic District |
| Charleston Navy Yard Officers' Quarters Historic District |
| Charleston's French Quarter District |
| Charlotte Avenue-Aiken Avenue Historic District |
| Charlton Hall Plantation House |
| Cheraw Historic District |
| Chesnut Cottage |
| Chester City Hall and Opera House |
| Chester Historic District |
Data from United States Park Service and Wikidata
