Pennsylvania - Area of significance: Commerce
| New Kensington Downtown Historic District |
| Newlin Mill Complex |
| New Market |
| Newport Historic District |
| New Ringgold Gristmill |
| New Thomson House |
| Newtown Historic District |
| Nitre Hall |
| North East Historic District |
| Northern Liberties Historic District |
| Northern National Bank |
| N. Snellenburg Company Department Store Warehouse |
| Ohringer Building |
| Oil City Downtown Commercial Historic District |
| Oil City South Side Historic District |
| Old Brown's Mill School |
| Old City Historic District |
| Old Conemaugh Borough Historic District |
| Old Customshouse |
| Old Downtown Harrisburg Commercial Historic District |
| Old Economy |
| Old Federal Reserve Bank |
| Old Mauch Chunk Historic District |
| Old Rose Tree Tavern |
| Oregon Mill Complex |
| Oxford Hotel |
| Packer, Asa, Mansion |
| Packwood House-American Hotel |
| Parker's Ford |
| Passenger and Baggage Car No. 4639 |
| Passenger Coach No. 3556 |
| Passenger Day Coach No. 8177 |
| Passenger Locomotive No. 1223 |
| Passenger Locomotive No. 1737 |
| Passenger Locomotive No. 460 |
| Passenger Locomotive No. 7002 |
| Penn Alto Hotel |
| Penn-Liberty Historic District |
| Pennock E. Sharpless House |
| Pennsbury Inn |
| Penn's Park General Store Complex |
| Penns Park Historic District |
| Pennsylvania Railroad Freight Building |
| Peoples Bank Building, The |
| Perikomen Bridge Hotel |
| Philadelphia Contributionship |
| Philadelphia Stock Exchange |
| Philadelphia Wholesales Drug Company Building |
| Philipsburg Historic District |
| Phillips Mill Historic District |
| Phipps-McElveen Building |
| Phoenixville Historic District |
| Physicians and Dentists Building |
| Pickle, Simon, Stone House |
| Pierce, Lukens, House |
| Pittsburgh Central Downtown Historic District |
| Pittsburgh Mercantile Company Building |
| Pittsburgh Terminal Warehouse and Transfer Company |
| Pleasureville Historic Historic |
| Point Pleasant Historic District |
| Portage Historic District |
| Potter-Allison Farm |
| Pottsville Downtown Historic District |
| Powelton Historic District |
| Powelton, The |
| Presque Isle Light |
| Provident Mutual Insurance Company |
| Reading Company Grain Elevator |
| Reading Terminal and Trainshed |
| Real Estate Building |
| Red Lion Borough Historic District |
| Red Run Lodge |
| Reed, Charles Manning, Mansion |
| Reilly Brothers and Raub Building |
| Reyburn Manufacturing Company Building |
| Reymer Brothers Candy Factory |
| Richardson, Joseph, House |
| Ridge Avenue Farmers' Market |
| Ringland Tavern |
| Riverside Hotel |
| River Street Historic District |
| Ross Common Manor |
| Roughwood |
| Rush House |
| Saltsburg Historic District |
| Sandy Hill Tavern |
| Scenery Hill Historic District |
| Schellsburg Historic District |
| Scherer, Frank C., Wagon Works |
| Schlicher, George F., Hotel |
| Schoonover Mountain House |
| Scottdale Historic District |
| Scranton Chamber of Commerce Building |
| Second National Bank of Meyersdale |
| Seel, William, Building |
| Seipsville Hotel |
| Sharples Homestead |
| Shaw Historic District |
| Shohola Glen Hotel |
| Short's Hotel |
Data from United States Park Service and Wikidata
