Pennsylvania - Area of significance: Commerce
| Silver Lake Bank |
| Skinner Tavern |
| South Bethlehem Downtown Historic District |
| Southwark Municipal Piers |
| Sprenger Brewery |
| Spring Grove Farm and Distillery |
| Spring Mill Complex |
| Springtown Historic District |
| Spring Valley Historic District |
| Steckel, Daniel, House |
| Steel Hopper Car No. 33164 |
| Steel Passenger Coach No. 1650 |
| Steel Passenger Coach No. 1651 |
| Stiegel-Coleman House |
| St. Marys Historic District |
| Stoddartsville Historic District |
| Stotesbury Club House |
| Stouchsburg Historic District |
| Stover-Myers Mill |
| Stover-Winger Farm |
| Stoystown Historic District |
| Strawbridge and Clothier Department Store Warehouse |
| Strawbridge and Clothier Store |
| Strip Historic District |
| Strode's Mill |
| Strode's Mill Historic District |
| Sugartown Historic District |
| Summit Hotel |
| Sunbury Historic District |
| Sun Oil Building |
| Swigart's Mill |
| Switcher No. 1670 |
| Switcher No. 94 |
| Tamaqua Historic District |
| Tannery, The |
| Taylor, Phillip, House |
| Terminal Commerce Building |
| Thomas Brothers Store |
| Titusville Historic District |
| Towanda Historic District |
| Townhouse Row |
| Trexler Historic District |
| Trostletown Bridge |
| Tulpehocken Creek Historic District |
| Tulpehocken Manor Plantation |
| Tunkhannock Historic District |
| Turn Store and the Tinsmith's Shop |
| Tyrone Borough Historic District |
| Uhlerstown Historic District |
| Union Canal Tunnel |
| Union Hotel |
| Uniontown Downtown Historic District |
| Unionville Village Historic District |
| Uptown Somerset Historic District |
| Wable-Augustine Tavern |
| Wagner's, Charlie, Cafe |
| Wallace-Baily Tavern |
| Wanamaker, John, Store |
| Warburton House |
| Warren Historic District |
| Warwick, The |
| Washington Commercial Historic District |
| Waynesboro Historic District |
| Waynesburg Historic District |
| Welles, Ellen and Charles F., House |
| Wellsboro Historic District |
| Wellsville Historic District |
| Werner, William, House |
| West 21st Street Historic District |
| West Alexander Historic District |
| West Chester Downtown Historic District |
| Western Division of the PA Canal |
| Western Division-Pennsylvania Canal |
| West Middletown Historic District |
| West Norristown Historic District |
| West Park Place |
| Whitehill-Gleason Motors |
| White Horse Tavern |
| White Horse Tavern |
| White House Inn |
| Wilkinsburg Historic District |
| William Penn Hotel |
| Williamsburg Historic District |
| Wilson, Levi, Tavern |
| Wilson, Robert, House |
| Witmer's Tavern |
| Wolf, Penrose, Building |
| Wollner Building |
| Wooden Baggage Express No. 6 |
| Wooden Express Baggage No. 6076 |
| Wooden Hopper Gondola No. 1818 |
| Woodward Inn |
| Wright’s Block |
| Wyalusing Borough Historic District |
| York Central Market |
| York Dispatch Newspaper Offices |
| York Historic District |
| Youghiogheny Bank of Pennslyvania |
| Zollinger-Harned Company Building |
Data from United States Park Service and Wikidata
