Ohio - Significance region: Local
| Salt House |
| Sanborn Hall |
| Sandiford, Robert, House |
| Sands, George F., School |
| Sandusky County Jail and Sheriff's House |
| Sandusky Street Historic District |
| Santa Clara Business Historic District |
| Sarchet-Burgess House |
| Sarchet, Peter B., House |
| Satterthwaite, John, House |
| Saunders, Elizabeth Sheets, Farm |
| Saunders Seed Company |
| Savage-Stewart House |
| Sawyer-Curtis House |
| Sawyer, Louis, House |
| Sawyer-Wayside House |
| Scarlet Oaks |
| Schaller Memorial Building |
| Schantz, Adam Sr., House |
| Schantz Organ Company |
| Schantz Park Historic District |
| Schine State Theatre |
| Schlee Brewery Historic District |
| Schlee-Kemmler Building |
| Schmick, Charles Nelson, House |
| Schmitt, Louis, House and Store |
| Schooley, Dr. Lindley, House and Office |
| Schriber, Hyman, Building |
| Schrock, Peter, Jr., Farm |
| Schuffenecker, August Building |
| Schulkers, Robert F., House |
| Schulte-United Building-G.C. Murphy’s Building |
| Schuter Carpenter Shop and House |
| Schweinfurth, Charles, House |
| Science Hill School |
| Scioto County Courthouse |
| Scioto Grange No. 1234 |
| Scioto Street Historic District |
| Scioto Township District No. 2 Schoolhouse |
| Scioto Township Works I |
| Scofield, Levi, House |
| Scott, John, Barn and Granary |
| Scott, Matthew, House |
| Scottown Covered Bridge |
| Scott, William, House |
| Scranton South Side Historic District |
| Scroggs House |
| Sears, A. B., House |
| Sears, Roebuck and Company |
| Seborn, Frederick Augustus, House |
| Sebring, Frank, House |
| Second Baptist Church |
| Second Hosack House |
| Second Presbyterian Church |
| Second Presbyterian Church |
| Second Street Historic District |
| Secor Hotel |
| Secor, Joseph K., House |
| Sedamsville River Road Historic District |
| Sedamsville Village Historic District |
| Seeley, Uri, House |
| Seely, Dr. John W., House |
| Seher, William, House |
| Seiberling, Charles Willard, House |
| Seip House |
| Selby Field |
| Selby, Orland, House |
| Selby Shoe Company Building |
| Selle Gear Company |
| Sells, Benjamin, Barn #1 |
| Sells, Benjamin, Barn #2 |
| Sells, Benjamin, House |
| Sells, Benjamin, Wash House |
| Sells, David, Barn |
| Sells, Eliud, House |
| Sells, William Henry, House |
| Seneca Hotel |
| Serquet, Emanuel and Frederick, Farm |
| Sessions House |
| Seville Inn |
| Seville Jail |
| Seymour, William H., House |
| Shaker Farm Historic District |
| Shambaugh, George, House |
| Sharon Center Public Square Historic District |
| Sharon Township Town Hall |
| Sharp, Morris, House |
| Sharp, Samuel, House |
| Sharp, Stephen, House |
| Shaub, Martin, Mill Site/House |
| Shawen Acres |
| Shaw Farm |
| Shawnee Hotel |
| Shaw, Samuel, Residence |
| Shaw, Sylvester, Residence |
| Sheets, Andrew, House |
| Sheffield Village Hall |
| Shelby Center Historic District |
| Shelby House |
| Sheltering Arms Hospital |
Data from United States Park Service and Wikidata
