North Carolina - Significance region: Local
| Rural Hall Depot |
| Russell School |
| Rutherfordton-Spindale Central High School |
| Ryder Hall |
| Saint Agnes Church |
| Saint Catherine of Siena Catholic Church |
| Salem Methodist Church |
| Salem Methodist Church |
| Salem Street Historic District |
| Salem Town Hall |
| Salisbury Railroad Corridor Historic District |
| Salisbury Street Historic District |
| Salisbury VA Hospital Historic District |
| Salter-Battle Hunting and Fishing Lodge |
| Saluda Main Street Historic District |
| Salvo Post Office |
| Samuel James and Jessie McCune Childs House |
| S And W Cafeteria |
| Sandy Point |
| Sanford High School, Former |
| Sanford Tobacco Company Redrying Plant and Warehouse |
| Santeetlah Hydroelectric Development |
| Satulah Mountain Historic District |
| Savage, Dr. J. A., House |
| Savage, William and Susan, House |
| Savona Mill |
| Saxapahaw Spinning Mill, Former |
| Scales, Alfred Moore, Law Office |
| Scarborough House |
| Scarborough, Maj. James, House |
| Schaub, John Jacob, House |
| Schley Grange Hall |
| Scotch Hall |
| Scotland Neck Historic District |
| Scott and Roberts Dry Cleaning Plant, Office, and Store |
| Scott, Thomas, House |
| Seaboard Air Line Passenger Depot |
| Seaboard Air Line Railroad Passenger Station |
| Seaboard Air Line Railway Depot |
| Seaboard Milling Company |
| Seabord Historic District |
| Sea Foam Motel |
| Seagle, Andrew, Farm |
| Seavey, Dr. John B., House and Cemetery |
| Second Street Historic District |
| Second Yadkin County Jail |
| Sedberry-Holmes House |
| Seifart, Fritz, House |
| Self-Trott-Bickett House |
| Seven Gables |
| Seven Hearths |
| Seven Oaks |
| Seventh Avenue Depot District |
| Seventy-First Consolidated School |
| Sewell, Dillard B. and Georgia, House |
| Shackford Hall |
| Shady Oaks |
| Sharpe, Col. Silas Alexander, House |
| Sharpe-Gentry Farm |
| Shaver Rental Houses District |
| Shaw-Cude House |
| Shaw Family Farms |
| Shaw House |
| Shaw House |
| Shelby Cotton Mill |
| Shelter Neck Historic District |
| Shelton House |
| Shepard Street-South Road Street Historic District |
| Sheppard, Thomas, Farm |
| Sherman, Elijah, Farm |
| Sherrill, John Carlyle and Anita, House |
| Sherrill, Miles Alexander, House |
| Sherrod Farm |
| Sherrod Park |
| Sherwood, Michael, House |
| Shiloh African Methodist Episcopal Zion Church |
| Shiloh Presbyterian Church Cemetery |
| Shiloh Primitive Baptist Church |
| Shoaf, Henry, Farm |
| Shook-Welch-Smathers House |
| Shuford-Hoover House |
| Shuford House |
| Shultz, Christian Thomas, House |
| Shuping's Mill Complex |
| Shutt, John Edward Belle, House and Outbuildings |
| Siceloff, J. C., House |
| Sidney Cotton Mill |
| Siler City City Hall |
| Siler City Commercial Historic District |
| Siler City High School |
| Siler, Jesse R., House |
| Siloam School |
| Silvermont |
| Singletary-Reese-Robinson House |
| Skewarkey Primitive Baptist Church |
| Skinner, Dr. Charles and Susan, House and Outbuildings |
| Skinnerville-Greenville Heights Historic District |
| Skyline Lodge |
| Sledge-Hayley House |
| Sloan, Dr. David Dickson, Farm |
Data from United States Park Service and Wikidata
