North Carolina - Significance region: Local
| Sloan, Dr. Earl S., House |
| Sloan-Throneburg Farm |
| Small, G. Milton, and Associates, Office Building |
| Small House |
| Smathers, Frank, House |
| Smith, Benjamin, House |
| Smith Clinic |
| Smith, Dr. Ezekiel Ezra, House |
| Smithfield Masonic Lodge |
| Smith, Francis Marion, House |
| Smith, Frank and Mary, House |
| Smith Jr., Isaac H., House |
| Smith, Richard Sharp, House |
| Smith, Turner and Amelia, House |
| Smith, W. F., and Sons Leaf House and Brown Brothers Company Building |
| Smith, Whitford G., House |
| Smithwick's Creek Primitive Baptist Church |
| Smith, William E., House |
| Smith, William G., House |
| Smith, William Rankin and Elizabeth Wharton, House |
| Smith-Williams-Durham Boarding House |
| Snipes-Fox House |
| Snowbird Mountain Lodge |
| Snow Camp Mutual Telephone Exchange Building |
| Snow Creek Methodist Church and Burying Ground |
| Snow Hill Colored High School |
| Snow Hill Historic District |
| Snugs, Isaiah Wilson, House, and Marks House |
| Snyder, John Wesley, House |
| Sosnik-Morris-Early Commercial Block |
| South Asheville Cemetery and St. John ‘A’ Baptist Church |
| South Aspen Street Historic District |
| South Benbow Road Historic District |
| South Brick House |
| South Broad-East Fifth Streets Historic District |
| South Broad Street Row |
| Southerland-Burnette House |
| Southern Asbestos Company Mills |
| Southern Pines Historic District |
| Southern Railway Depot |
| Southern Railway Freight Station |
| Southern Railway Passenger Car Number 1211 |
| Southern Railway Passenger Station |
| South Greensboro Historic District |
| South King Street Historic District |
| South Main Street Historic District |
| South Montreat Road Historic District |
| Southport Historic District |
| South Race Street Historic District |
| South River Presbyterian Church |
| South Trade Street Houses |
| South Union Street Courthouse and Commercial Historic District |
| South Union Street Historic District |
| Southwest Historic District |
| Sowers, Philip, House |
| Spears House |
| Speas Vinegar Company |
| Speas, William Henry and Sarah Hauser, House |
| Speed Farm |
| Speight-Bynum House |
| Speight House and Cotton Gin |
| Sperling, George, House and Outbuildings |
| Spinning Wheel |
| Spoon, A. L., House |
| Spread Out Historic District |
| Spring Green Primitive Baptist Church |
| Spring Hill |
| Spring Hope Historic District |
| Spruce Street YMCA |
| Sprunt, James D. and Frances, Cottage |
| Spurgeon House |
| SS. Peter and Paul's Russian Orthodox Greek Catholic Church |
| Stagg House |
| St. Alban's Episcopal Church |
| Stallings-Carpenter House |
| St. Ambrose Episcopal Church |
| Stamey Company Store |
| Standard Drug No. 2 |
| St. Andrews Presbyterian College |
| Stanley Mills |
| Stanly, Edward R., House |
| Star Historic District |
| Statesville Commercial Historic District |
| St. Athanasius Episcopal Church and Parish House and the Church of the Holy Comforter |
| Stauber, Samuel B., Farm |
| St. Barnabas Episcopal Church |
| Stedman, Frank H., House |
| Steele Creek Presbyterian Church and Cemetery |
| Stepp's Mill |
| Sterling Cotton Mill |
| Sternberger, Sigmund, House |
| Stevens, Wayland H. and Mamie Burt, House |
| St. Frances Methodist Church |
| Stillwell, Erle, House |
| Stillwell, Erle, House II |
| St. James Episcopal Church and Rectory |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Missionary Baptist Church |
Data from United States Park Service and Wikidata
