North Carolina - Area of significance: Architecture
| Shamrock Mills |
| Sharpe, Col. Silas Alexander, House |
| Sharpe-Gentry Farm |
| Shaver Rental Houses District |
| Shaw-Cude House |
| Shaw Family Farms |
| Shaw House |
| Shaw House |
| Shelby Cotton Mill |
| Shell Castle |
| Shelton House |
| Shelton Plantation House |
| Shepard Street-South Road Street Historic District |
| Sheppard, Thomas, Farm |
| Sherman, Elijah, Farm |
| Sherrill, John Carlyle and Anita, House |
| Sherrill, Miles Alexander, House |
| Sherrill's Inn |
| Sherrod Farm |
| Sherrod Park |
| Sherwood, Michael, House |
| Shiloh Primitive Baptist Church |
| Shoaf, Henry, Farm |
| Shook-Welch-Smathers House |
| Shuford-Hoover House |
| Shuford House |
| Shultz, Christian Thomas, House |
| Shuping's Mill Complex |
| Shutt, John Edward Belle, House and Outbuildings |
| Siceloff, J. C., House |
| Sidney Cotton Mill |
| Sikes, John C., House |
| Siler City City Hall |
| Siler City Commercial Historic District |
| Siler City High School |
| Siler, Jesse R., House |
| Siloam School |
| Silvermont |
| Single Brothers' House |
| Singletary-Reese-Robinson House |
| Skeen's Mill Covered Bridge |
| Skewarkey Primitive Baptist Church |
| Skinner, Dr. Charles and Susan, House and Outbuildings |
| Skinnerville-Greenville Heights Historic District |
| Skyline Lodge |
| Sledge-Hayley House |
| Sloan, Dr. David Dickson, Farm |
| Sloan, Dr. Earl S., House |
| Sloan-Throneburg Farm |
| Sloop Point |
| Slover-Bradham House |
| Small, G. Milton, and Associates, Office Building |
| Small House |
| Smallwood, Eli, House |
| Smathers, Frank, House |
| Smith, Benjamin, House |
| Smith Clinic |
| Smithfield Masonic Lodge |
| Smith, Francis Marion, House |
| Smith, Frank and Mary, House |
| Smith-McDowell House |
| Smith, Richard Sharp, House |
| Smith, Turner and Amelia, House |
| Smith Warehouse |
| Smith, W. F., and Sons Leaf House and Brown Brothers Company Building |
| Smith, Whitford G., House |
| Smith-Whitford House |
| Smithwick's Creek Primitive Baptist Church |
| Smith, William E., House |
| Smith, William G., House |
| Smith, William Rankin and Elizabeth Wharton, House |
| Smith-Williams-Durham Boarding House |
| Snipes-Fox House |
| Snowbird Mountain Lodge |
| Snow Creek Methodist Church and Burying Ground |
| Snow Hill Colored High School |
| Snow Hill Historic District |
| Snugs, Isaiah Wilson, House, and Marks House |
| Snyder, John Wesley, House |
| Somerset Place State Historic Site |
| Sosnik-Morris-Early Commercial Block |
| South Aspen Street Historic District |
| South Benbow Road Historic District |
| South Brick House |
| South Broad-East Fifth Streets Historic District |
| South Broad Street Row |
| Southerland-Burnette House |
| Southern Pines Historic District |
| Southern Railway Depot |
| Southern Railway Freight Station |
| Southern Railway Passenger Depot |
| Southern Railway Passenger Station |
| South Greensboro Historic District |
| South King Street Historic District |
| South Main Street Historic District |
| South Montreat Road Historic District |
| Southport Historic District |
| South Race Street Historic District |
| South River Presbyterian Church |
| South Trade Street Houses |
Data from United States Park Service and Wikidata
