North Carolina - Area of significance: Architecture
| South Union Street Courthouse and Commercial Historic District |
| South Union Street Historic District |
| Southwest Historic District |
| Sowers, Philip, House |
| Spears House |
| Speas Vinegar Company |
| Speas, William Henry and Sarah Hauser, House |
| Speight-Bynum House |
| Speight House and Cotton Gin |
| Spencer Historic District |
| Sperling, George, House and Outbuildings |
| Spinning Wheel |
| Spoon, A. L., House |
| Spray Industrial Historic District |
| Spread Out Historic District |
| Spring Green Primitive Baptist Church |
| Spring Hope Historic District |
| Spruce Street YMCA |
| Sprunt, James D. and Frances, Cottage |
| Spurgeon House |
| SS. Peter and Paul's Russian Orthodox Greek Catholic Church |
| Stagg House |
| Stagville |
| St. Alban's Episcopal Church |
| Stallings-Carpenter House |
| St. Ambrose Episcopal Church |
| Stamey Company Store |
| St. Andrew's Episcopal Church and Cemetery |
| St. Andrews Presbyterian College |
| Stanly, Edward R., House |
| Stanly, John Wright, House |
| Star Historic District |
| Statesville Commercial Historic District |
| St. Athanasius Episcopal Church and Parish House and the Church of the Holy Comforter |
| Stauber, Samuel B., Farm |
| St. Barnabas Episcopal Church |
| Stedman, Frank H., House |
| Steele Creek Presbyterian Church and Cemetery |
| Sterling Cotton Mill |
| Sternberger, Sigmund, House |
| Stevens, Everitt P., House |
| Stevenson House |
| Stevens, Wayland H. and Mamie Burt, House |
| Stewart-Hawley-Malloy House |
| St. Frances Methodist Church |
| Stigerwalt, John, House |
| Stillwell, Erle, House |
| Stillwell, Erle, House II |
| St. James Episcopal Church and Rectory |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Missionary Baptist Church |
| St. Joseph African Methodist Episcopal Church |
| St. Joseph's Catholic Church |
| St. Joseph's Episcopal Church |
| St. Lawrence, Patrick, House |
| St. Luke's Church and Cemetery |
| St. Luke's Episcopal Church |
| St. Luke's Episcopal Church |
| St. Luke's Lutheran Church Cemetery |
| St. Mark's Episcopal Church |
| St. Mark's Episcopal Church |
| St. Mary's Chapel |
| St. Mary's Chapel |
| St. Mary's Church |
| St. Mary's College |
| St. Matthew's Episcopal Church and Churchyard |
| St. Matthew's Lutheran Church |
| St. Matthias Episcopal Church |
| Stockton |
| Stokes County Courthouse |
| Stokesdale Historic District |
| Stone, Daniel, Plank House |
| Stone Hedge |
| Stone, Joseph B., House |
| Stonewall |
| Stonewall Jackson Training School Historic District |
| Stovall, John W., Farm |
| St. Paul A.M.E. Church |
| St. Paul Baptist Church |
| St. Paul's Church and Cemetery |
| St. Paul’s Episcopal Church |
| St. Paul's Episcopal Church and Cemetery |
| St. Paul's Episcopal Church and Churchyard |
| St. Paul's Methodist Episcopal Church South |
| St. Paul's Reformed Church |
| St. Paul's Roman Catholic Church |
| St. Philip's Church Ruins |
| St. Philip's Episcopal Church |
| St. Philip's Episcopal Church |
| St. Philip's Moravian Church |
| Strange, Robert, Country House |
| Strawberry Hill |
| Strawberry Hill |
| St. Stephen United Methodist Church |
| St. Thomas Episcopal Church |
| Stuart Motor Company |
Data from United States Park Service and Wikidata
