Missouri - Significance region: Local
| Schneider, Henry, Building |
| Schnier, Fred, Building |
| Schollmeyer Building |
| Schowengerdt, Ernst, House |
| Schroer, J. F., House-Store |
| Schwegmann, John F., House |
| Scott County Courthouse |
| Scottish Rite Cathedral |
| Scruggs-Vandervoort-Barney Warehouse |
| Scudder Motor Truck Company Building |
| Sears, Roebuck and Company Warehouse Building |
| Second Baptist Church |
| Second Baptist Church and Booker T. Washington School Historic District |
| Security Building |
| Sedalia Commercial Historic District |
| Seed, Miles A., Carriage House |
| Sehrt, August, House |
| Selkirk, Ben J. and Sons, Building |
| Seven Gables Building |
| Seven Oaks School |
| Seventh District Police Station |
| Seven-Up Company Headquarters |
| Sewall Paint and Glass Company Building |
| Shady Grove Cemetery |
| Shamrock Court |
| Shankman Building |
| Shaughnessy, Martin, Building |
| Shaw's Garden Historic District |
| Shelby-Nicholson-Schindler House |
| Shelby, Thomas, House |
| Shell Building, The |
| Shelley, William Francis, House |
| Sherwood Manufacturing Company Building |
| Shivelbine, August and Amalia, House |
| Shobe-Morrison House |
| Shriners' Hospital for Crippled Children |
| Sickles Tavern |
| Sigma Alpha Epsilon Building |
| Sikeston St. Louis, Iron Mountain and Southern Railway Depot |
| Simmons Colored School |
| Simonsen School |
| Simpson's College |
| Simpson-Yeomans-Country Side Historic District |
| Slatten House |
| Sligo Iron Store Co. Buildings |
| Smallin Cave Historic District |
| Smith Academy and Manual Training School |
| Smith, Dr. E. Sanborn, House |
| Smith, Orie J., Black and White Stock Farm Historic District |
| Smith, W.J. and Ed, Building |
| Snelson-Brinker House |
| Sojourners Club |
| Sophian Plaza |
| Soulard Neighborhood Historic District |
| Soulard-Page District |
| South Avenue Commercial Historic District |
| Southeast Grand Avenue and Fifth Street Residential Historic District |
| Southeast Green Street Historic Cottage District |
| Southeast Missourian Building |
| Southeast Third Street and Southeast Corder Avenue Ranch House Historic District |
| Southeast Third Street Residential Historic District |
| South Fourth Street Commercial District |
| South Fourth Street Commercial Historic District |
| South Hyde Park Historic District |
| South Liberty Courthouse Square Historic District |
| South Main Street Historic District |
| South Main Street Historic District |
| South-McDaniel-Patton Commercial Historic District |
| South Middle Street Historic District |
| South Side Historic District |
| South Side National Bank |
| South Sixth Street Historic District |
| Southwestern Bell Administration Building |
| Southwestern Bell Repeater Station-Wright City |
| Southwest Market Street Historic District |
| Southwest Third and Southwest Madison Historic District |
| Sowers, Peter J., House |
| Spaunhorst and Mayn Building |
| Speck District |
| Speigle House |
| S. Pfeiffer Manufacturing Company Headquarters |
| Spofford Home for Children |
| Spool Cotton Co. Building |
| Spratt-Allen-Aull House |
| Springfield Furniture Company |
| Springfield Grocer Company Warehouse |
| Springfield Public Square Historic District |
| Springfield Seed Co. Office and Warehouse |
| Springfield Warehouse and Industrial Historic District |
| Squibb, E.R. and Sons, Building |
| Squier Park Historic District |
| S.S. Cyril and Methodius Historic District |
| Stafford-Olive Historic District |
| St. Albans Farms Stone Barn |
| St. Albans General Store |
| Standard Adding Machine Building |
| Standard Stamping Company Factory |
| Star Bucket Pump Company Building |
| Starke-Meinershagen-Boeke Rural Historic District |
| Staudinger-Grumke House-Store |
Data from United States Park Service and Wikidata
