Missouri - Significance region: Local
| St. Augustine`s Roman Catholic Church |
| St. Boniface Neighborhood Historic District |
| St. Cecilia Historic District |
| St. Charles Odd Fellows Hall |
| Steelcote Manufacturing Company Paint Factory |
| Ste. Genevieve Historic District |
| St. Elizabeth Hospital |
| Stenzel, R.O. & Company, Warehouse |
| Stephens College, South Campus |
| Stephens, Hugh and Bessie, House |
| Stevens, Edward A., House |
| St. Ferdinand Avenue in The Ville Historic District |
| St. Francis de Sales Church |
| St. Francis de Sales Historic District |
| St. Francis Xavier Catholic Church and Rectory |
| St. Francis Xavier School |
| St. Francois County Jail and Sheriff's Residence |
| Stickney, William A., Cigar Company Building |
| Stine and McClure Undertaking Company Building |
| "Stix, Baer and Fuller Dry Goods Company's ""Grand Leader"" Relay Station" |
| St. James A.M.E. Church |
| St. James Chapel |
| St. Joe Lead Company Administration Building |
| St. John's Evangelical Lutheran Church and Parochial School |
| St. John’s High School and Seminary |
| St. John's Mercy Hospital Building |
| St. Joseph Church |
| St. Joseph City Hall |
| St. Joseph Park and Parkway System |
| St. Joseph Public Library |
| St. Joseph Public Library-Carnegie Branch |
| St. Joseph's Commerce and Banking Historic District |
| St. Jude's Episcopal Church |
| St. Louis and San Francisco Railroad Building |
| St. Louis Colored Orphans Home |
| St. Louis Globe-Democrat Building |
| St. Louis, Iron Mountain and Southern Railroad Depot |
| St. Louis, Iron Mountain and Southern Railroad Depot |
| St. Louis Mart and Terminal Warehouse |
| St. Louis News Company |
| St. Louis Place Historic District |
| St. Louis Post-Dispatch Building |
| St. Louis Post-Dispatch Printing Building |
| St. Louis Post-Dispatch Rotogravure Printing Plant |
| St. Louis-San Francisco Railroad Depot |
| St. Louis Stamping Company Buildings |
| St. Louis Theatre |
| St. Ludger Catholic Church |
| St. Luke's Hospital Historic District |
| St. Luke's Plaza Apartments |
| St. Mark the Evangelist Catholic Church, Convent and Academy |
| St. Mary of Victories Church |
| St. Mary's Episcopal Church |
| St. Mary's Infirmary |
| St. Mary's Institute of O'Fallon |
| St. Matthew's Chapel A.M.E. Church |
| Stockstrom, Charles, House |
| Stockton Community Building |
| Stockton, Robert Henry, House |
| Stoddard County Courthouse |
| Stonebrook |
| Stone Chapel |
| Stone County Courthouse |
| Stone Houses |
| Stone Row |
| Stork Inn |
| St. Oswald's Protestant Episcopal Church |
| Stoutimore, David L. and Sallie Ann, House |
| Stowe Teachers College |
| St. Paul Block |
| St. Paul's Church |
| St. Peter's Catholic Church |
| St. Peter's Episcopal Church |
| St. Peter the Apostle Catholic Church and Rectory |
| St. Philip's Episcopal Church |
| Stramcke, Thomas Talbot and Rebecca Walton Smithers, House |
| Strassberger's Conservatory |
| St. Regis Hotel |
| St. Teresa's Academy Music and Arts Building |
| Studna Garage Building |
| Stumbaugh Post No. 180 GAR Hall |
| Stumberg, Dr. John H., House |
| St. Vincent De Paul Catholic Church |
| Summer Public School |
| Sumner, Charles, High School |
| Sunset Tower |
| Susan Cave (23WA190) |
| Sutter-Meyer House |
| Swan Creek Bridge |
| Sweeney Automobile and Tractor School |
| Sweet Springs Historic District |
| Swinney, E.F., School |
| Switzer School Buildings |
| Sylvan School |
| Tamm, George, Building |
| Tandy Community Center |
| Taylor, John N. and Elizabeth, House |
| Taylor-Olive Building |
| Ten Main Center |
| Tergin Apartment Building |
Data from United States Park Service and Wikidata
