Missouri - Significance region: Local
| Quality Hill Center Historic District |
| Queen, Harrison, House |
| Quincy, Missouri, and Pacific Railroad Station |
| Quincy, Omaha and Kansas City Railroad Office Building |
| Quincy Public Hall |
| Quinn Chapel AME Church |
| Raaf, Joseph, House |
| Rail Haven Motel |
| Railway Exchange Building |
| Rainey Funeral Home Building |
| Rains Brothers Building |
| Ramsey Accessories Manufacturing Corporation |
| Rankin Hall |
| Rannells, Charles S. and Mary Warder, House |
| Ray, A., Taylor House |
| Ray County Courthouse |
| Ray County Poor Farm |
| Reber Place Historic District |
| Redding-Hill House |
| Remington Rand Building |
| Repp, William D., House |
| Reynolds, James, House |
| Rhoda, Fred, House |
| Rice-Stix Building, The |
| Richards and Conover Hardware Company Building |
| Richardson, John D., Dry Goods Company |
| Richland Christian Church |
| Richter, Theodore and Lena, House |
| Ridenour-Baker Grocery Company Building |
| Ridgway Apartments |
| Rieger Hotel |
| Riggio Building |
| Riggs, Absolom, House |
| Ripley County Courthouse |
| Ripley County Jail, Sheriff's Office and Sheriff's Residence |
| Ritchey, Mathew H., House |
| Riverview Park |
| R. J. DeLano School for Crippled Children |
| Roaring River Camps and Hotel Summer Cottage |
| Robert, Johnson and Rand-International Shoe Company Complex |
| Roberts Chevrolet |
| Roberts Farmstead |
| Roberts, J.F., Octagonal Barn |
| Robidoux Hill Historic District |
| Robidoux Row |
| Robidoux School |
| Robinson, George R. and Elsie, House |
| Robinson, William, P., House |
| Robnett-Payne House |
| Rock Fountain Court Historic District |
| Rock House, Edgewood Children's Center |
| Rock Spring School |
| Rockwell, Bertrand, House |
| Rockwood Court Apartments |
| Rodgers Theatre Building |
| Roeschel-Toennes-Oswald Property |
| Rolla Ranger Station Historic District |
| Rose Fanning Elementary School |
| Ross House |
| Rott School |
| Rotunda, The |
| Round Spring Archeological District |
| Route 66 Steak 'n Shake |
| Row House Building |
| Row House Buildings (Boundry Increase) |
| Royal Tire Service Inc. Building |
| Rozier, Louis J. and Harriet, House |
| Russell Hotel |
| Ruthven, John B. and Elizabeth, House |
| Rutledge School |
| Ryan Block |
| Sacred Heart Church, School and Rectory |
| Safeway No. 357 |
| Safeway Stores and Office and Warehouse Building |
| Sage Chapel Cemetery |
| Saint Louis Provident Association Building |
| Saint Matthew's Parish Complex |
| Saint Paul's Episcopal Church |
| Salisbury School |
| Salisbury Square Historic District |
| Sancta Maria in Ripa |
| Sander, Augustus, House |
| Sanford Avenue Historic District |
| Sanford B. Ladd School |
| Sanitol Building |
| Sanning, P.A., Store |
| Santa Fe Place Historic District |
| Sappington, Joseph, House |
| Sappington, Zephaniah, House |
| Saratoga Lanes Building |
| Sarcoxie Public Square Historic District |
| Saverton School |
| Savings Trust Company of St. Louis |
| Savoy Hotel and Grill |
| Scarritt, Edward Lucky, House |
| Scarritt Point North Historic District |
| Scarritt Point South Historic District |
| Scarritt, Rev. Nathan, House |
| Schmidt, Charles J. and Clara B. House |
| Schmitt, Anton, House |
Data from United States Park Service and Wikidata
