Mississippi - Significance region: Local
| Standard Drug Company |
| Starkville Colored Cemetery |
| States Area Neighborhood Historic District |
| Steele, L. C., House |
| Stephenson-Allen House |
| Stevens-Buchanan House |
| Stevenson Primary School |
| Stewart-Anderson House |
| St. Mary's By the River |
| St. Matthew Evangelical Lutheran Church |
| Stogner House |
| Stone, John M., Cotton Mill |
| Stone-Reid House |
| Stonewall Mill Village Historic District |
| Storer House |
| St. Patrick Catholic Church |
| Strawberry Patch-McKay House |
| Stringer House |
| Sub Rosa |
| Summer Trees |
| Sumrall-Albritton House |
| Sunnyslope |
| Superintendent's Home at Columbia Training School |
| Suter House |
| Sweethome Mound |
| Swetman, Glenn, House |
| Sycamore Street Historic District |
| Sykes-Leigh House |
| Symons House |
| Tabernacle Methodist Church |
| Tabor, Dr. Joseph A., House |
| Taborian Hospital |
| Tanglewood |
| Tanglewood |
| Tansy Island Hunting Club Camp Site and Clubhouse |
| Tate County Agricultural High School Historic District |
| Tate County Courthouse |
| Taylorsville Signal Office and Watkins General Store |
| Temple B'nai Israel |
| Texada Tavern |
| The Raymond House |
| Thompson, George, House |
| Thompson, James Young, House |
| Thompson, June and Nora, House |
| Thompson School |
| Tibbee School |
| Tilda Bogue |
| Tillman House |
| Town of Palo Alto |
| Traveller's Rest |
| Tri-State Motor Coach Station |
| Truly House |
| Tucker House |
| Tunica Historic District |
| Tupelo Downtown Neighborhood Historic District |
| Turcotte House |
| Turkey Creek Community Historic District |
| Turnage House |
| Tye House |
| Tynes House |
| Una Consolidated School |
| Union Church Presbyterian Church |
| Union County Courthouse |
| Union Earthworks |
| Union Hotel |
| Union Station |
| Union Station Historic District |
| Upper Midtown Historic District |
| Upper West Central Historic District |
| Upriver Residential District |
| Uptown Vicksburg Historic District |
| U.S. District Courthouse |
| U.S. Post Office |
| U.S. Post Office |
| U.S. Post Office |
| U.S. Post Office |
| U.S. Post Office |
| U.S. Post Office |
| U.S. Post Office |
| U.S. Post Office |
| US Post Office |
| US Post Office and Courthouse |
| US Post Office and Customhouse |
| U.S. Post Office, Courthouse, and Customhouse |
| US Post Office-Crystal Springs |
| US Post Office-Forest |
| US Post Office-Grenada |
| US Post Office-Hazlehurst |
| US Post Office-Magnolia |
| US Post Office, Old |
| US Post Office, Old-Ripley |
| US Post Office (Philadelphia), Old |
| US Post Office-Water Valley |
| US Sugar Crop Field Station |
| Vaiden High School |
| Vancleave Cottage |
| Van Court Town House |
| Vernal Presbyterian Church |
| Vicksburg Public Library, Old |
| Virden-Patton House |
Data from United States Park Service and Wikidata
