Mississippi - Significance region: Local
| Raiford, Robert, Home and Farm |
| Railroad Section Foreman's House |
| Rankin County Confederate Monument |
| Rankin County Courthouse |
| Ravenna |
| Raymond Historic District |
| Rea, Dr. Robert W., House |
| Rea, James Samuel, House |
| Rebecca Site |
| Redding House |
| Reid House |
| Reynoir Street Historic District |
| Richland |
| Ricks Memorial Library |
| Rienzi Commercial Historic District |
| Ripley Historic District |
| River Road and Western Downtown Residential Historic District |
| Riverside Plantation |
| Robbins House |
| Robertson, Smith, Elementary School |
| Robertson-Yates House |
| Rogers, Emma and Ed, House |
| Rogers, Francis M., House |
| Rogers House |
| Rolling Acres Historic District |
| Roos House |
| Rose, Adolph, Building |
| Rosedale Historic District |
| Rosedale Plantation |
| Rose Hill Missionary Baptist Church |
| Rosemary-Humphreys House |
| Ruleville Depot |
| Sadler House |
| Saenger Theater |
| Saenger Theatre |
| Saint Mark's Episcopal Church |
| Salem School, Old |
| Sand Spring Presbyterian Church |
| Saragossa |
| Saunders-Paine House, The |
| Scales, William Henry, House |
| Scherck, R. T., House |
| Scherer House |
| Scranton Historic District |
| Seashore Campground School |
| Second Street Historic District |
| Sedgewood Plantation |
| Selma Plantation House |
| Shadyside |
| Shaw Homestead |
| Shaw-Nosser House |
| Shelton House |
| Shlenker House |
| Short's Hill |
| Shrock House |
| Shubuta Baptist Church |
| Shubuta Methodist Episcopal Church, South |
| Simmons Farmhouse |
| Simmons House |
| Simmons House |
| Simmons & Wright Company, The |
| Simpson County Courthouse |
| Sims-Brown House |
| Sims House |
| Smart-Griffin House |
| Smith, A. L., House |
| Smith, Charles F., House |
| Smithland |
| Smith-McClain-Buckley House |
| Smith Park Architectural District |
| Smyth, Benjamin Franklin, House |
| Soria City Historic District |
| South Central Aberdeen Historic District |
| South Cherry Street Historic District |
| South Church Street Historic District |
| South College Street Historic District |
| South Division Street Historic District |
| South Drummond Street Neighborhood Historic District |
| Southeast Senatobia Historic District |
| South Lamar Historic District |
| South Main Historic District |
| South Panola Street Historic District |
| Southside Neighborhood Historic District |
| Southtown Historic District |
| South Vicksburg Public School No. 200 |
| South Ward Street Historic District |
| Southwest Gulfport Historic District |
| Southwest Midtown Historic District |
| Southworth House |
| Spain House |
| Spann, Pearl, Elementary School |
| Spengler's Corner |
| Spengler's Corner Historic District |
| Spengler-Thomas Building |
| Spight, F. L., House |
| Spinks Plantation |
| Springhill Cemetery |
| Spring Hill Missionary Baptist Church |
| Stafford's Wells Hotel |
| Stamp’s Super Burgers |
Data from United States Park Service and Wikidata
