Mississippi - Significance region: Local
| New Liberty School |
| New Orleans and Great Northern Railroad Depot-Tylertown |
| New Orleans and Northeastern Railroad Depot |
| New Orleans Great Northern Railroad Depot |
| New Orleans Great Northern Railroad Passenger Depot |
| Newsom - Adams Family Farm House |
| Newsom-Lane House |
| Newsom-Smith House |
| Newton West Church Historic District |
| New York, The |
| Niles House |
| Niles, Judge Henry C., House |
| Niolon Building |
| Noel, Gov. Edmund F., House |
| North Aberdeen Historic District |
| North Broadway Historic District |
| North Church Primary School |
| North Elm Historic District |
| North Lamar Historic District |
| North Main Street Historic District |
| North Manor Apartments |
| North Panola Street Historic District |
| North Park Street Historic District |
| Norwood-TWL Building |
| N & W Overall Company Building |
| Oakes, Augustus J., House |
| Oakland |
| Oaks Historic District |
| Oaks, The |
| Oakwood |
| Odd Fellows and Confederate Cemetery |
| Odd Fellows Cemetery |
| O'Keefe-Clark Boarding House |
| Okolona College |
| Okolona Historic District |
| Oktibbeha Gardens Subdivision Historic District |
| Old Augusta Historic Site |
| Old Bay St. Louis Historic District |
| Old Brickyard Place |
| Old Depot Restaraunt and Lounge |
| Old Farmers and Merchants State Bank |
| Old Natchez Trace (132-3T) |
| Old Natchez Trace (170-30) |
| Old Natchez Trace (212-3K 213-3K) |
| Old Natchez Trace (230-3H) |
| Old Noxubee County Jail of 1870 |
| Old Ocean Springs High School |
| Old Ocean Springs Historic District |
| Old Philadelphia Church |
| Old Superintendent's House, Tupelo Fish Hatchery |
| Old Terminal Building, Hawkins Field |
| Old Tishomingo County Courthouse |
| Old Water and Electric Light Plant |
| Oliver House |
| Olsen, Lena, House |
| Orange Avenue Historic District |
| Outlaw, Dossey A., Plantation |
| Overstreet School Historic District |
| Owen-Richardson-Owen House |
| Parker-Summerfield Mound Archeological Site |
| Parkhaven Historic District |
| Parsons, C. H., House |
| Pascagoula Central Fire Station No. 1 |
| Pascagoula High School, Old |
| Pascagoula Street Railroad and Power Company |
| Patterson, Charles, House |
| Paxton House |
| Pearl Street Historic District |
| Peoples Bank and Trust Company |
| Peoples Bank of Biloxi |
| Perkins House |
| Pheba Historic District |
| Philadelphia Historic District |
| Phoenix Hall-Johnson-Harper House |
| Pigford Building |
| Pilgrim's Rest |
| Pinewood |
| Pittman Log House |
| Pleasant Hill |
| Pleasant Hill |
| Pleasant Valley Methodist Church |
| Poindexter Park Historic District |
| Polk-Sherard-Hinman House |
| Pontotoc Historic District |
| Poplar Hill Grade School |
| Porter-Crawford House |
| Porter House |
| Porterville General Store |
| Port Gibson High School (Old) |
| Powell-Vail House |
| Prairie Plantation House |
| Prentiss Club |
| Price-Patton-Pettis House |
| Price-Stephens House |
| Providence Cemetery |
| Provine House |
| Purnell, James C., House |
| Quarles, W. J., House and Cottage |
| Quitman Depot |
| Quitman Downtown-Mill Historic District |
Data from United States Park Service and Wikidata
