Massachusetts - Significance region: National
| Monument Square Historic District |
| Mount Auburn Cemetery |
| Mount, The |
| Murphy, William, House |
| Myles Standish Burial Ground |
| Myles Standish Park and Myles Standish House Site |
| Nantucket Historic District |
| Naumkeag |
| Nauset Archeological District |
| Naval Hospital Boston Historic District |
| Nell, William C., House |
| New Bedford Historic District |
| Newburyport Historic District |
| New England Conservatory of Music |
| Norfolk County Courthouse |
| Northampton State Hospital |
| North Canal Historic District |
| North Easton Historic District |
| North Easton Railroad Station |
| Old Burial Hill |
| Old City Hall |
| Old Corner Bookstore |
| Old Deerfield Village Historic District |
| Old Harvard Yard |
| Old King's Highway Historic District |
| Old Manse |
| Old North Church |
| Old Schwamb Mill |
| Old Ship Meetinghouse |
| Old South Church in Boston |
| Old South Meeting House |
| Old State House |
| Old West Church |
| Olmsted, Frederick Law, House, National Historic Site |
| Olmsted Park System |
| Orchard House |
| Orrock, Rev. John, House |
| Otis, (First) Harrison Gray, House |
| Otis, (Second) Harrison Gray, House |
| Paine Estate |
| Paine, Robert Treat, Jr., House |
| Parkman, Francis, House |
| Parsonage, The |
| Parting Ways Archeological District |
| PAUL PALMER (Shipwreck and Remains) |
| Peabody Museum of Salem |
| Peirce-Nichols House |
| Perkins Estate |
| Phinney, William and Jane, House |
| Phipps Street Burying Ground |
| Piano Row District |
| Pierce-Hichborn House |
| Pilgrim Hall |
| Plymouth Rock |
| Plymouth Village Historic District |
| Ponakin Bridge |
| Provincetown Historic District |
| PT BOAT 796 (torpedo boat) |
| Putnam, Gen. Israel, House |
| Putnam, Gen. Rufus, House |
| Quincy Granite Railway |
| Quincy Granite Railway Incline |
| Quincy Homestead |
| Quincy, Josiah, House |
| Quincy Market |
| Quincy Town Hall |
| Rea-Proctor Homestead |
| Red Top |
| Reservoir Park |
| Revere Beach Reservation |
| Revere Beach Reservation Historic District |
| Revere, Paul, House |
| Rhodehouse, Nelson, House |
| Richards, Ellen H. Swallow, House |
| Richards, Theodore W., House |
| Ritchie Building |
| Rogerson's Village Historic District |
| ROSEWAY (schooner) |
| Rotch, William J., Gothic Cottage |
| Rotch, William Jr., House |
| Roughwood |
| Royall, Isaac, House |
| Rumford, Count, Birthplace |
| Rust, Nathaniel, Mansion |
| Saint Aidan's Church and Rectory |
| Saint Mary of the Assumption Church, Rectory, School and Convent |
| Saint Paul's Church, Chapel, and Parish House |
| Saint Paul's Rectory |
| Salem Maritime National Historic Site |
| Salem Village Historic District |
| Sandy Neck Cultural Resources District |
| Santuit Historic District |
| Sargent's Pond |
| Saugus Iron Works National Historic Site |
| Scituate Light |
| Searles Castle |
| Sears, David, House |
| Second Unitarian Church |
| Sever Hall, Harvard University |
| Shirley-Eustis House |
Data from United States Park Service and Wikidata