Massachusetts - Significance region: National
| Shubert, Sam S., Theatre |
| Six Moon Hill Historic District |
| Sleepy Hollow Cemetery |
| Smith, Matthias, House |
| South Green Historic District |
| South Station Headhouse |
| Spencer-Pierce-Little House |
| Springfield Armory |
| Spurr, Eliphalet, House |
| Standish, James H., House |
| Stevens Linen Works Historic District |
| Story, Joseph, House |
| Stoughton, Mary Fisk, House |
| St. Paul's Church |
| Strathmore Road Historic District |
| St. Stephen's Church |
| Suffolk County Jail |
| Suffolk Resolves House |
| Sumner, Charles, House |
| Symphony Hall |
| Taunton State Hospital |
| Thayer, Gen. Sylvanus, House |
| Thomas-Webster Estate |
| Thomson, Elihu, House |
| Thoreau-Alcott House |
| Torpedo Boat PT-617 |
| Toussaint, Winand, House |
| Town Stable |
| Tremont Street Subway |
| Trinity Church |
| Trinity Rectory |
| Trotter, William Monroe, House |
| Tuckerman, William F., House |
| Tufts, Peter, House |
| Twin Lights Historic District-Cape Ann Light Station |
| Twitchell, Ginery, House |
| Union Oyster House |
| United First Parish Church (Unitarian) of Quincy |
| United States Whip Company Complex |
| University Hall, Harvard University |
| U.S. Customhouse |
| US Customhouse |
| U.S. Marine Hospital at Vineyard Haven |
| USS CASSIN YOUNG (destroyer) |
| U.S.S. CONSTITUTION |
| U.S.S. JOSEPH P. KENNEDY JR. (DD-850) |
| USS LIONFISH (SS0298) National Historic Landmark |
| USS MASSACHUSETTS (BB-59) National Historic Landmark |
| Vale, The |
| Wade House |
| Wakefield Rattan Co. |
| Walden Pond |
| Walnut Hills Cemetery |
| Ward, Gen. Artemas, Homestead |
| Ward, John, House |
| Water Shops Armory |
| Watertown Arsenal Historic District |
| Wayside Inn Historic District |
| Wayside, The |
| Webster, Daniel, Law Office and Library |
| Weeks, Barzillai, House |
| Wesleyan Grove |
| West Barnstable Village-Meetinghouse Way Historic District |
| West Street District |
| Whipple, John, House |
| White, Benjamin, House |
| White Place Historic District |
| Whitman, Josiah B., House |
| Whitney & Company |
| Whittier, John Greenleaf, Homestead (Haverhill) |
| Whittier, John Greenleaf, House |
| Wianno Historic District |
| Wilbur Theatre |
| Wilson, Shoreborne, House |
| Winchester Square Historic District |
| Wirth, Jacob, Buildings |
| WITCH (catboat) |
| Woburn Public Library |
| Wright's Tavern |
Data from United States Park Service and Wikidata
