Massachusetts - Significance region: Local
| Sherburne, Warren E., House |
| Sherman Apartments Historic District |
| Sherman, Eber, Farm |
| Sherman, William B., Farm |
| Shirley Center Historic District |
| Shirley Village Historic District |
| Shoe Shop-Doucette Ten Footer |
| Short's Tavern |
| Shrewsbury Historic District |
| Shumway Block |
| Sibley-Corcoran House |
| Sidelinger, George A., House |
| Silver Hill Historic District |
| Simcock House |
| Simmons Block |
| Simond, Col. Benjamin, House |
| Simonds Tavern |
| Simonds, William, House |
| Simpson, Clara, Three-Decker |
| Simpson, Dr. Thomas, House |
| Simpson, James E., House |
| Sirna, Anthony and Allison, Studio |
| Skillings Estate House |
| Slade Spice Mill |
| Smith, A. C., & Co. Gas Station |
| Smith Alumnae Gymnasium |
| Smith, Bradford, Building |
| Smith Carriage Company District |
| Smith, Ellen M., Three-Decker |
| Smith, James, House |
| Smith-Lyon Farmhouse |
| Smith, Marshall, House |
| Smith, Perez, House |
| Smith, Samuel, Tavern Site |
| Smith's Building |
| Smith Shoe Shop |
| Smith, Thomas and Esther, House |
| Smuggler's House |
| Snow Fountain and Clock |
| Snow, Lemuel, Jr., House |
| Society of the Congregational Church of Great Barrington |
| Soldiers and Sailors Memorial Building |
| Soldiers' Memorial Library |
| Somerset Village Historic District |
| Somerville High School |
| Somerville Journal Building |
| Somerville Theatre |
| South Amherst Common Historic District |
| Southampton Center Historic District |
| Southborough Center Historic District |
| South Boston Boat Clubs Historic District |
| South Boston Naval Annex Historic District |
| Southbridge Town Hall |
| South Burying Ground |
| South Center School House |
| South Chatham Village Historic District |
| South Congregational Church |
| South Egremont Village Historic District |
| South End District |
| South Harwich Methodist Church |
| South Hingham Historic District |
| South Junior High School |
| South Lancaster Engine House |
| South Lee Historic District |
| South Main Street School |
| South Middleborough Historic District |
| South Reading Academy |
| South School |
| South School |
| South Street Historic District |
| South Swansea Union Church |
| South Union School |
| South Washington Street Historic District |
| Southwick-Daniels Farm |
| Southwick House |
| South Worthington Historic District |
| South Yarmouth/Bass River Historic District |
| Spaulding Block |
| Spear, Seth, Homestead |
| Spencer Town Center Historic District |
| Spicket Falls Historic District |
| Spot Pond Archeological District |
| Sprague House |
| Spring Brook Cemetery |
| Springfield District Court |
| Springfield Fire & Marine Insurance Co. |
| Springfield Safe Deposit and Trust Company |
| Springfield Steam Power Company Block |
| Springfield Street Historic District |
| Spring Hill Cemetery |
| Spring Hill Historic District |
| Spring Hill Historic District |
| Springside Park |
| Spurr, John, House |
| Stacy Building |
| Stacy, George O., House |
| Stafford Hill Memorial |
| Standish, Alexander, House |
| Stanley, Leonard W., House |
| Stanton, Jacob, House |
Data from United States Park Service and Wikidata
