Massachusetts - Area of significance: Commerce
| New Boston Village Historic District |
| Newburyport Historic District |
| New England Confectionery Company Factory |
| Newspaper Row |
| Newton Upper Falls Historic District |
| Norcross Brothers Houses |
| Norcross, William, House |
| North Amherst Center Historic District |
| Northampton Downtown Historic District |
| North Andover Center Historic District |
| North Attleborough Town Center Historic District |
| North Brookfield Town House |
| North Canal Historic District |
| North Downtown Historic District |
| North Falmouth Village Historic District |
| North High Street Historic District |
| Northside Historic District |
| Northside Village Historic District |
| Norwell Village Area Historic District |
| Octagon House |
| Oddfellows Building |
| Odd Fellow's Hall |
| Odd Fellows' Hall |
| Old Cambridge Historic District |
| Old Harbor U.S. Life Saving Station |
| Old Mill |
| Old Shipbuilder's Historic District |
| Old State Mutual Building |
| Old Third District Courthouse |
| Old Town Bridge |
| Old Town Hall Historic District |
| Old Village Historic District |
| Olmsted-Hixon-Albion Block |
| Orange Center Historic District |
| O'Shea Building |
| Otis Company Mill No. 1 |
| Oxford Main Street Historic District |
| Padanaram Village Historic District |
| Paine Furniture Building |
| Palmer Island Light Station |
| Parker, Capt. Nathaniel, Red House |
| Parker House |
| Parker, Samuel, House |
| Parkhill Mill |
| Patton and Loomis Block |
| Patton Building |
| PAUL PALMER (Shipwreck and Remains) |
| Peabody, John P., House |
| Penniman, Edward, House and Barn |
| Pequoig Hotel |
| Perkins Estate |
| Phoenix Building |
| Pierce, Peter, Store |
| Pinkham, Lydia, House |
| Pleasant Street Historic District |
| Plimpton-Winter House |
| Plymouth Antiquarian House |
| Plymouth Light Station |
| Plymouth Village Historic District |
| Plympton Village Historic District |
| PORTLAND (Shipwreck and Remains) |
| Port Royal House |
| Provincetown Historic District |
| Publicity Building |
| Puritan House |
| Quincy Granite Railway |
| Quincy Market |
| Radding Building |
| Railroad Hotel |
| Rawson, Warren, Building |
| Rehoboth Village Historic District |
| Republican Block |
| Richardson Block |
| Robert, Clovis, Block |
| Rockland Trust Company |
| Rocks Village Historic District |
| Roebuck Tavern |
| Rosebud, The |
| ROSEWAY (schooner) |
| Roughan Hall |
| Russell Corner Historic District |
| Safety Fund National Bank |
| Sage, Philemon, House |
| Salem Common Historic District |
| Salem Diner |
| Salem Landry |
| Salem Maritime National Historic Site |
| Sanborn House |
| Sanderson, Julia, Theater |
| Sanger, Richard, III, House |
| Santuit Historic District |
| Sawin, Ezekiel, House |
| Sears' Crescent and Sears' Block |
| Sears Roebuck and Company Mail Order Store |
| Sea Street Historic District |
| Second O'Shea Building |
| Sever, William, House |
| S. Gourse & Sons Block |
| Shattuck, Ralph W., House |
| Shawsheen Village Historic District |
Data from United States Park Service and Wikidata