Massachusetts - Area of significance: Commerce
| Sheffield Center Historic District |
| Shelburne Falls Historic District |
| "Shell Oil Company ""Spectacular"" Sign" |
| Shumway Block |
| Simonds Tavern |
| Slade Spice Mill |
| Smith, Bradford, Building |
| Smith, F.W., Silver Company |
| Smith, Samuel, Tavern Site |
| Smith's Building |
| Somerville Journal Building |
| Somerville Theatre |
| South Hadley Canal Historic District |
| South Middleborough Historic District |
| South Yarmouth/Bass River Historic District |
| Spaulding Block |
| Spencer Town Center Historic District |
| Springfield Fire & Marine Insurance Co. |
| Springfield Safe Deposit and Trust Company |
| Staples, Sylvanus N., House |
| Stark Building |
| Stearns Building |
| Stearns, R. H., House |
| Sterling Center Historic District |
| Stetson Hall |
| Sturbridge Common Historic District |
| Summer Street Historic District |
| Sutton Block |
| Sutton Center Historic District |
| Swampscott Fish House |
| Tack Factory, The |
| Taunton Green Historic District |
| Tavern Farm, Old |
| Ted's Diner |
| Temple Building |
| Temple Place Historic District |
| Templeton Common Historic District |
| Thayer, Nathaniel, Estate |
| Third Street Commercial Corridor Historic District |
| Thom Block |
| Thompson Street School |
| Times and Olympia Buildings |
| Tobin's Beach Site (Boundary Increase) |
| Town Diner |
| Trinity Block |
| Turner Falls Historic District |
| Union Oyster House |
| Union Street Historic District |
| Union Street Railway Carbarn, Repair Shop |
| Union Trust Company Building |
| Union Wharf |
| United Shoe Machinery Corporation Building |
| Uphams Corner Historic District |
| Upham's Corner Market |
| Upper North Street Commercial District |
| US Customhouse |
| Uxbridge Common District |
| Varnum Building |
| Vermont Building |
| Vickery-Baylies House |
| Vickery, Capt. David, House |
| Waitt Brick Block |
| Walden Street Cattle Pass |
| Walker Building |
| Wamesit Canal-Whipple Mill Industrial Complex |
| Wamsutta Mills |
| War Memorial Park |
| Warren Block |
| Washington Street Historic District |
| Washington Street Shoe District |
| Wason-Springfield Steam Power Blocks |
| Waters, Asa, Mansion |
| Wayland Center Historic District |
| WCIS Bank |
| Webster-Lane House |
| Weldon Hotel |
| Wells Block |
| Wenham Historic District |
| West Barnstable Village-Meetinghouse Way Historic District |
| West Brookfield Center Historic District |
| Westfield Center Commercial Historic District |
| Westfield Center Historic District |
| West Gardner Square Historic District |
| West Main Street Historic District |
| Westminster Village-Academy Hill Historic District |
| Westport Point Historic District |
| West Stockbridge Town Hall |
| White Place Historic District |
| Whitney, Israel, House |
| Whitney Tavern |
| Whit's Diner |
| Wigglesworth Building |
| Wilson, Capt. John, House and Bates Ship Chandlery |
| Wilson's Diner |
| Winchendon Village Historic District |
| Winchester Center Historic District |
| Winchester Savings Bank |
| Winchester Square Historic District |
| Winter Island Historic District and Archeological District |
| Wirth, Jacob, Buildings |
Data from United States Park Service and Wikidata
