Kentucky - Significance region: Local
| Seventh Street School |
| Shady Grove |
| Shady Rest |
| Shafer's Hall |
| Shake Rag Historic District |
| Shallcross |
| Shanklin House |
| Sharp House |
| Sharpsburg Historic District |
| Shawnee Elementary School |
| Shawnee High School |
| Shawnee Neighborhood Historic District |
| Shearer Store |
| Sheehan House |
| Shelburne-Cox House |
| Shelburne, Perry, House |
| Shelby Academy |
| Shelby County Courthouse and Main Street Commercial District |
| Shelby Park Branch Library |
| Shelby Park Historic District |
| Shelbyville L & N Railroad Depot |
| Sherley Mansion |
| Sherman Tavern |
| Shinkle, Amos, Summer Residence |
| Shipp House |
| Shobe, Moses, House |
| Shopville Elementary School |
| Short, George, House |
| Showalter House |
| Shropshire Farm |
| Shropshire House |
| Simeon Lewis Rural Historic District |
| Simmons House |
| Simpson Log House |
| Simpsonville Christian Church |
| Simpsonville Methodist Church |
| Simrall-Warfield House |
| Site Bn-54 |
| Skees, Richard, House |
| Skees, William, House |
| Slaton, James E., House |
| Sleadd, William, Farm |
| Sloss, John, House |
| Smith, Beecher, House |
| Smith, Col. Robert A., Monument |
| Smith, David H., House |
| Smith, Dr. William Addison, House |
| Smith, Enoch, House |
| Smith, F. A., House |
| Smith, George and Nellie White, House |
| Smith, George W., House |
| Smith House |
| Smith House |
| Smith, Maj. Hampden, House |
| Smith, Mitchell Baker, Company Building |
| Smith, Nelson and Clifton Rodes, House |
| Smiths Grove Baptist Church |
| Smiths Grove District |
| Smiths Grove Presbyterian Church |
| Smith, William Alexander, House |
| Smith-Williams House |
| Smoketown Historic District |
| Snapp House |
| Snell, Perry, Hall |
| Snook House |
| Snook, Van B., House |
| Snow Hill |
| Soaper, William, Farm |
| Soldiers and Sailors Memorial Gymnasium |
| Soldiers Retreat |
| Somerset Armory |
| Somerset City School and Carnegie Library |
| Somerset Downtown Commercial District |
| Sousley, Franklin R., Birthplace |
| South Broadway Neighborhood District |
| South Central Bell Company Office Building |
| South Cherry Street Historic District |
| South Courthouse Square Historic District |
| Southeast Greyhound Line Building |
| Southeast Lexington Residential and Commercial District |
| Southern Heights-Beechmont District |
| Southern Railway Passenger Depot |
| South Frankfort Neighborhood Historic District |
| Southgate House |
| South Greenup District |
| South Hill Historic District |
| South Louisville Reformed Church |
| South Main and South Elm Streets Historic District |
| South Main Street Historic District |
| South Main Street Historic District |
| South Park Neighborhood |
| Southwest Glasgow Residential District |
| Spalding, Leonard A., House |
| Spears-Craig House |
| Speed Building |
| Speed Hall |
| Sprigg, William, House |
| Springfield Armory |
| Springfield Main Street Historic District |
| Springfield Presbyterian Church |
Data from United States Park Service and Wikidata
