Kentucky - Significance region: Local
| Spring Garden-John Leavell |
| Springhill |
| Spring Hill |
| Spring Hill Farm |
| Spring Hill (Thomas Lillard House) |
| Springview Farm |
| Squire Turner House |
| Stacey Hotel |
| Stader Hotel |
| Stadium |
| Stafford, Francis M., House |
| St. Aloysius Church |
| Stambaugh Church of Christ |
| Stambaugh House |
| Stamper, Hiram and Art, House |
| Standard Oil Company Filling Station |
| Stanford Commercial District |
| Stansbury, Zack, House |
| St. Anthony's Roman Catholic Church, Rectory, Convent, and School |
| Stapleton Farm |
| Stapp Homeplace |
| Stark House |
| State Theatre |
| St. Augustine Catholic Church |
| St. Augustine Church Complex |
| St. Bartholomew Parish School |
| St.Bonifacius Kirche Complex |
| St. Cecilia School Building |
| St. Columba Catholic Campus |
| Stearns Administrative and Commercial District |
| Stearns Golf Course |
| Steele, Drewsilla, House |
| St. Elizabeth of Hungary Roman Catholic Church |
| St. Elmo School |
| Stephen Foster Elementary School |
| Stephens, J.Q.A., House |
| Stephenson House |
| Sterrett House |
| Stevens, John, House |
| Stevenson, Dr. John E., House |
| Stevenson, Henry, House |
| Stewart, Dr. Edward S., House |
| Stewart, G. W., House |
| Stewart House |
| Stewart's Dry Goods Company Building |
| Stewart, W.K., Bookstore |
| St. Francis DeSales Roman Catholic Church |
| St George's Roman Catholic Church |
| Stidger, Felix Grundy, House |
| Stilley House |
| Stinnett, James L., House |
| Stitzel, Arthur P., House |
| Stivers, Zodia, House |
| St. James AME Church |
| St. James AME Church |
| St. James Apartments |
| St. Jerome's Catholic Church Complex |
| St. John United Methodist Church |
| St. Joseph Church |
| St. Joseph Church |
| St. Joseph Roman Catholic Church |
| St. Joseph's District |
| St. Luke Catholic Church |
| St. Lukes Church |
| St. Mildred's Court-West Lexington Avenue Historic Distric t |
| Stockton-Ray House |
| Stone Bridge at Chaplin Creek |
| Stone Historic District |
| Stoner Creek Rural Historic District |
| Stony Point |
| Stout, Ben, House |
| St. Patrick's Roman Catholic Church, Rectory, and School |
| St. Paul's Episcopal Church |
| St. Paul's German Evangelical Church and Parish House |
| St. Peters AME Church |
| St. Philips Episcopal Church |
| Struss House |
| St. Therese Church |
| St. Therese Roman Catholic Church, School, and Rectory |
| St. Thomas Episcopal Church |
| Stuart Building |
| Stuart, John, House |
| Stucky House |
| Sturgeon-Gregg House |
| St. Vincent DePaul Church, Rectory, School, St. Ursula Home and Convent |
| St. Vincent de Paul School |
| Sugar Grove |
| Suggett, William, Agricultural and Industrial District |
| Sullen Possum Site |
| Sulphur Well Historic District |
| Sunnyside |
| Sunnyside Farm House |
| Superintendent's House |
| Sutfield House |
| Sutfield-Thompson House |
| Swann, W.G., Tobacco Company |
| Sweeney, James J., House |
| Swindler House |
| Swope-Dudderar House and Mill Site |
| Tabernacle, The |
Data from United States Park Service and Wikidata
