Florida - Area of significance: Commerce
| Richloam General Store and Post Office |
| Roberts Farm Historic and Archeological District |
| Rogers Building |
| Rossetter, James Wadsworth, House |
| Royal Poinciana Way Historic District |
| Russ, Joseph W., Jr., House |
| Ryan & Company Lumber Yard |
| SAN FELIPE Shipwreck Site |
| Sanford Commercial District |
| Sanibel Lighthouse and Keeper's Quarters |
| Sanitary Public Market |
| SAN PEDRO (shipwreck) |
| Sarasota County Chamber of Commerce Building |
| Seaboard Airline Railroad Station |
| Sears, Roebuck and Company Department Store |
| Sebring Downtown Historic District |
| Security Building |
| Seminole Inn |
| Sherman Arcade |
| Smallwood, Ted, Store |
| Smith, Archie, Wholesale Fish Company |
| Smith, H. W., Building |
| Solla-Carcaba Cigar Factory |
| South Beach Street Historic District |
| South River Drive Historic District |
| Spanish Fleet Survivors and Salvors Camp Site |
| Star Garage |
| St. Augustine Beach Hotel and Beachfront |
| St. Augustine Town Plan Historic District |
| St. Cloud Downtown Historic District |
| St. John's Lighthouse |
| St. Marks Lighthouse |
| Stranahan House |
| Stuart Welcome Arch |
| Studebaker Building |
| Sunset Hotel |
| Tarpon Springs Historic District |
| Tenney House and Groveland Hotel |
| Thiesen Building |
| Thompson Fish House, Turtle Cannery and Kraals |
| Tinker Building |
| Title & Trust Company of Florida Building |
| Titusville Commercial District |
| Townsend Building |
| Townsend, James W., House |
| Townsend, James W., House |
| Triangle Inn |
| Tween Waters Inn Historic District |
| Union Bank |
| Union Depot Hotel, Old |
| Union Terminal Company Warehouse |
| Upper North Franklin Street Commercial District |
| URCA DE LIMA (shipwreck) |
| USS ALLIGATOR |
| Valencia Hotel and Arcade |
| Vero Railroad Station |
| Vero Theatre |
| Via Mizner |
| Village Store |
| Wahnish Cigar Factory and Tobacco Warehouse |
| Walgreen Drug Store |
| Warner, J. W., House |
| Well'sbuilt Hotel |
| West Tampa Historic District |
| Wheeler-Evans House |
| Whidden's Marina |
| White Springs Historic District |
| Wild Cow Prairie Cemetery |
| Winecoff House |
| Winter Garden Downtown Historic District |
| Worth's Block |
| Wright, James W., Building |
| Ximenez-Fatio House |
| Ybor City Historic District |
| Yulee Sugar Mill Ruins |
Data from United States Park Service and Wikidata
