Colorado - Significance region: Local
| Dey Building |
| Deza Estates |
| Dickens Opera House |
| Dickinson Branch Library |
| District No. 17 School-Medlen School |
| Dixon-Markle House |
| Dodge-Hamlin House |
| Dolores River Bridge |
| Doud, John and Elvira, House |
| Douglas Crossing Bridge |
| Downtown Boulder Historic District |
| Downtown Denver Central YMCA and Annex |
| Downtown Florence Historic District |
| Downtown Longmont Historic District |
| Downtown Loveland Historic District |
| Downtown Sterling Historic District |
| Dow-Rosenzweig House |
| Doyle-Benton House |
| Drennan School |
| Duke, Nathaniel W., House |
| Dumont School |
| Dunning-Benedict House |
| Dunraven Cottage-Camp Dunraven |
| Dunwoody, William J., House |
| Durango High School |
| Dutzi, Howard & Ruth, House |
| Dyer, Samuel, House |
| Eads Community Church |
| Eads School Gymnasium |
| Earl School |
| Earnest Ranch |
| East High School |
| Eastholme |
| East Inlet Trail |
| Eastlake Farmers Co-Operative Elevator Company |
| East Longs Peak Trail-Longs Peak Trail-Keyhole Route-Shelf Trail |
| East Side Historic District |
| East Street School |
| East Third Avenue Historic Residential District |
| Eaton, Aaron James, House |
| Echo Lake Park |
| Edgemont |
| Edgeplain |
| Edgerton House |
| Eighth Street Baptist Church |
| Eldora Historic District |
| Eleventh Avenue Hotel |
| Elkhorn Lodge |
| El Monte Hotel |
| El Paso County Courthouse |
| El Pomar Estate |
| El Pueblo |
| Elsner, John, House |
| Emerick, Charles, House |
| Emerson School |
| Emily Griffith Opportunity School |
| Emmanuel Presbyterian Church |
| Emmanuel Shearith Israel Chapel |
| Empire Chief Mine and Mill |
| Empson Cannery |
| EM Ranch |
| Engelbrecht Farm |
| Engine No. 463 |
| Englewood I.O.O.F. Lodge No. 138 Building |
| Enterprise Hill Historic District |
| Eppich Apartments |
| Ertel Funeral Home |
| Estabrook Historic District |
| Evans-Elbert Ranch |
| Evans Homestead Rural Historic Landscape |
| Evans, J.G., Barn |
| Evans Memorial Chapel |
| Evans School |
| Evergreen Cemetery |
| Evergreen Conference District |
| Evergreen Corner Rural Historic District |
| Everhardt Ranch |
| Exon & Rush Meat Market and Mercantile |
| Fairplay Hotel |
| Fall River Pump House and Catchment Basin |
| Farmers State Bank of Cope |
| Fay, William and Anna, House |
| Fern Lake Trail |
| Fetz-Keller Ranch Headquarters |
| Field, Eugene, House |
| Fillius Park |
| Finney, Dr. Frank, House |
| Fire Station No. 1 |
| Fire Station No. 3 |
| First Avenue Hotel |
| First Baptist Church |
| First Baptist Church |
| First Baptist Church |
| First Baptist Church of Boulder |
| First Baptist Church of Denver |
| First Baptist Church of Moffat |
| First Baptist Church of Salida |
| First Christian Church |
| First Congregational Church |
| First Congregational Church |
Data from United States Park Service and Wikidata
